tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2023 Sep 15;10(10)
fad464.
doi: 10.1093/ofid/ofad464. eCollection 2023 Oct. Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia in Patients Treated With Anti-CD20 Monoclonal Antibodies
Nadav Furie[SUP] 1 2 [/SUP], Michal Mandelboim[SUP] 2 3 [/SUP], Neta Zuckerman[SUP] 2 3 [/SUP], Ana Belkin[SUP] 4 5 [/SUP], Lior Seluk[SUP] 1 2 [/SUP], Inbal Shafran[SUP] 1 2 [/SUP], Ronen Mass[SUP] 1 [/SUP], Liran Levy[SUP] 1 2 [/SUP], Sumit Chatterji[SUP] 1 [/SUP], Erik Baltaxe[SUP] 1 2 [/SUP], Michael Peled[SUP] 1 2 [/SUP], Tiberiu Shulimzon[SUP] 1 [/SUP], Abraham Avigdor[SUP] 2 6 [/SUP], Sharon Amit[SUP] 7 [/SUP], Amir Onn[SUP] 1 2 [/SUP], Edith M Marom[SUP] 2 8 [/SUP], Galia Rahav[SUP] 2 5 [/SUP], Michael J Segel[SUP] 1 2 [/SUP]
Affiliations
We report 8 cases of persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia in patients previously treated with anti-CD20 monoclonal antibodies. Polymerase chain reaction of nasopharyngeal swabs for SARS-CoV-2 was negative in most cases; viral cell cultures confirmed that viable SARS-Co-2 virus was present. Four patients were treated with anti-SARS-CoV-2 hyperimmune globulins with rapid resolution of disease.
Keywords: COVID19; SARS-CoV-2; antibody therapy; immune globulins; monoclonal antibody.
. 2023 Sep 15;10(10)
fad464.doi: 10.1093/ofid/ofad464. eCollection 2023 Oct. Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia in Patients Treated With Anti-CD20 Monoclonal Antibodies
Nadav Furie[SUP] 1 2 [/SUP], Michal Mandelboim[SUP] 2 3 [/SUP], Neta Zuckerman[SUP] 2 3 [/SUP], Ana Belkin[SUP] 4 5 [/SUP], Lior Seluk[SUP] 1 2 [/SUP], Inbal Shafran[SUP] 1 2 [/SUP], Ronen Mass[SUP] 1 [/SUP], Liran Levy[SUP] 1 2 [/SUP], Sumit Chatterji[SUP] 1 [/SUP], Erik Baltaxe[SUP] 1 2 [/SUP], Michael Peled[SUP] 1 2 [/SUP], Tiberiu Shulimzon[SUP] 1 [/SUP], Abraham Avigdor[SUP] 2 6 [/SUP], Sharon Amit[SUP] 7 [/SUP], Amir Onn[SUP] 1 2 [/SUP], Edith M Marom[SUP] 2 8 [/SUP], Galia Rahav[SUP] 2 5 [/SUP], Michael J Segel[SUP] 1 2 [/SUP]
Affiliations
- PMID: 37808896
- PMCID: PMC10551847
- DOI: 10.1093/ofid/ofad464
We report 8 cases of persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia in patients previously treated with anti-CD20 monoclonal antibodies. Polymerase chain reaction of nasopharyngeal swabs for SARS-CoV-2 was negative in most cases; viral cell cultures confirmed that viable SARS-Co-2 virus was present. Four patients were treated with anti-SARS-CoV-2 hyperimmune globulins with rapid resolution of disease.
Keywords: COVID19; SARS-CoV-2; antibody therapy; immune globulins; monoclonal antibody.