tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2023 Jun 8;10(7)
fad311.
doi: 10.1093/ofid/ofad311. eCollection 2023 Jul. Propensity-Score Matched Analysis of the Effectiveness of Baricitinib in Patients With Coronavirus Disease 2019 (COVID-19) Using Nationwide Real-World Data: An Observational Matched Cohort Study From the Japan COVID-19 Task Force
Hiromu Tanaka[SUP] 1 [/SUP], Shotaro Chubachi[SUP] 1 [/SUP], Ho Namkoong[SUP] 2 [/SUP], Yasunori Sato[SUP] 3 [/SUP], Takanori Asakura[SUP] 1 [/SUP], Ho Lee[SUP] 1 [/SUP], Shuhei Azekawa[SUP] 1 [/SUP], Shiro Otake[SUP] 1 [/SUP], Kensuke Nakagawara[SUP] 1 [/SUP], Takahiro Fukushima[SUP] 1 [/SUP], Mayuko Watase[SUP] 1 [/SUP], Kaori Sakurai[SUP] 1 [/SUP], Tatsuya Kusumoto[SUP] 1 [/SUP], Yasushi Kondo[SUP] 4 [/SUP], Katsunori Masaki[SUP] 1 [/SUP], Hirofumi Kamata[SUP] 1 [/SUP], Makoto Ishii[SUP] 1 [/SUP], Yuko Kaneko[SUP] 4 [/SUP], Naoki Hasegawa[SUP] 2 [/SUP], Soichiro Ueda[SUP] 5 [/SUP], Mamoru Sasaki[SUP] 5 [/SUP], Takehiro Izumo[SUP] 6 [/SUP], Minoru Inomata[SUP] 6 [/SUP], Naoki Miyazawa[SUP] 7 [/SUP], Yasuhiro Kimura[SUP] 7 [/SUP], Yusuke Suzuki[SUP] 8 [/SUP], Norihiro Harada[SUP] 9 [/SUP], Masako Ichikawa[SUP] 9 [/SUP], Tohru Takata[SUP] 10 [/SUP], Hiroyasu Ishikura[SUP] 11 [/SUP], Takashi Yoshiyama[SUP] 12 [/SUP], Hiroyuki Kokuto[SUP] 12 [/SUP], Koji Murakami[SUP] 13 [/SUP], Hirohito Sano[SUP] 13 [/SUP], Tetsuya Ueda[SUP] 14 [/SUP], Naota Kuwahara[SUP] 15 [/SUP], Akiko Fujiwara[SUP] 15 [/SUP], Takashi Ogura[SUP] 16 [/SUP], Takashi Inoue[SUP] 17 [/SUP], Takahiro Asami[SUP] 17 [/SUP], Yoshikazu Mutoh[SUP] 18 [/SUP], Ichiro Nakachi[SUP] 19 [/SUP], Rie Baba[SUP] 18 [/SUP], Koichi Nishi[SUP] 20 [/SUP], Mayuko Tani[SUP] 20 [/SUP], Junko Kagyo[SUP] 21 [/SUP], Mizuha Hashiguchi[SUP] 21 [/SUP], Tsuyoshi Oguma[SUP] 22 [/SUP], Koichiro Asano[SUP] 22 [/SUP], Masanori Nishikawa[SUP] 23 [/SUP], Hiroki Watanabe[SUP] 23 [/SUP], Yukinori Okada[SUP] 24 25 26 [/SUP], Ryuji Koike[SUP] 27 [/SUP], Yuko Kitagawa[SUP] 28 [/SUP], Akinori Kimura[SUP] 29 [/SUP], Seiya Imoto[SUP] 30 [/SUP], Satoru Miyano[SUP] 31 [/SUP], Seishi Ogawa[SUP] 32 [/SUP], Takanori Kanai[SUP] 33 [/SUP], Koichi Fukunaga[SUP] 1 [/SUP]
Affiliations
Background: To determine the effectiveness of baricitinib in patients with coronavirus disease 2019 (COVID-19), investigate whether baricitinib prevents the need for invasive mechanical ventilation and identify patient subgroups that would benefit from baricitinib.
Methods: This observational matched-cohort study was conducted by the Japan COVID-19 Task Force, a nationwide multicenter consortium. Patients with COVID-19 aged ≥18 years were identified from 70 hospitals in Japan. Among patients with confirmed COVID-19 from February 2020 to September 2021, those receiving baricitinib were propensity-score matched with controls.
Results: Among 3309 patients, 144 propensity score-matched pairs were identified. Thirteen (9.0%) patients in the baricitinib group and 27 (18.8%) in the control group required invasive mechanical ventilation during the disease course (odds ratio, 0.43). Although the baricitinib group had more severe disease, there were no significant differences in the intensive care unit admission rates (odds ratio, 1.16) and mortality rates (odds ratio, 0.74) between groups. In subgroup analyses, baricitinib was associated with a significant reduction in the need for invasive mechanical ventilation in patients requiring oxygen support (odds ratio, 0.28), with rapid shadow spread on chest radiography (odds ratio, 0.11), or treated with remdesivir (odds ratio, 0.27), systemic corticosteroids (odds ratio, 0.31), or anticoagulants (odds ratio, 0.17).
Conclusions: Baricitinib is effective at preventing the need for invasive mechanical ventilation in patients with COVID-19.
Keywords: COVID-19; baricitinib; invasive mechanical ventilation; real-world data.
. 2023 Jun 8;10(7)
fad311.doi: 10.1093/ofid/ofad311. eCollection 2023 Jul. Propensity-Score Matched Analysis of the Effectiveness of Baricitinib in Patients With Coronavirus Disease 2019 (COVID-19) Using Nationwide Real-World Data: An Observational Matched Cohort Study From the Japan COVID-19 Task Force
Hiromu Tanaka[SUP] 1 [/SUP], Shotaro Chubachi[SUP] 1 [/SUP], Ho Namkoong[SUP] 2 [/SUP], Yasunori Sato[SUP] 3 [/SUP], Takanori Asakura[SUP] 1 [/SUP], Ho Lee[SUP] 1 [/SUP], Shuhei Azekawa[SUP] 1 [/SUP], Shiro Otake[SUP] 1 [/SUP], Kensuke Nakagawara[SUP] 1 [/SUP], Takahiro Fukushima[SUP] 1 [/SUP], Mayuko Watase[SUP] 1 [/SUP], Kaori Sakurai[SUP] 1 [/SUP], Tatsuya Kusumoto[SUP] 1 [/SUP], Yasushi Kondo[SUP] 4 [/SUP], Katsunori Masaki[SUP] 1 [/SUP], Hirofumi Kamata[SUP] 1 [/SUP], Makoto Ishii[SUP] 1 [/SUP], Yuko Kaneko[SUP] 4 [/SUP], Naoki Hasegawa[SUP] 2 [/SUP], Soichiro Ueda[SUP] 5 [/SUP], Mamoru Sasaki[SUP] 5 [/SUP], Takehiro Izumo[SUP] 6 [/SUP], Minoru Inomata[SUP] 6 [/SUP], Naoki Miyazawa[SUP] 7 [/SUP], Yasuhiro Kimura[SUP] 7 [/SUP], Yusuke Suzuki[SUP] 8 [/SUP], Norihiro Harada[SUP] 9 [/SUP], Masako Ichikawa[SUP] 9 [/SUP], Tohru Takata[SUP] 10 [/SUP], Hiroyasu Ishikura[SUP] 11 [/SUP], Takashi Yoshiyama[SUP] 12 [/SUP], Hiroyuki Kokuto[SUP] 12 [/SUP], Koji Murakami[SUP] 13 [/SUP], Hirohito Sano[SUP] 13 [/SUP], Tetsuya Ueda[SUP] 14 [/SUP], Naota Kuwahara[SUP] 15 [/SUP], Akiko Fujiwara[SUP] 15 [/SUP], Takashi Ogura[SUP] 16 [/SUP], Takashi Inoue[SUP] 17 [/SUP], Takahiro Asami[SUP] 17 [/SUP], Yoshikazu Mutoh[SUP] 18 [/SUP], Ichiro Nakachi[SUP] 19 [/SUP], Rie Baba[SUP] 18 [/SUP], Koichi Nishi[SUP] 20 [/SUP], Mayuko Tani[SUP] 20 [/SUP], Junko Kagyo[SUP] 21 [/SUP], Mizuha Hashiguchi[SUP] 21 [/SUP], Tsuyoshi Oguma[SUP] 22 [/SUP], Koichiro Asano[SUP] 22 [/SUP], Masanori Nishikawa[SUP] 23 [/SUP], Hiroki Watanabe[SUP] 23 [/SUP], Yukinori Okada[SUP] 24 25 26 [/SUP], Ryuji Koike[SUP] 27 [/SUP], Yuko Kitagawa[SUP] 28 [/SUP], Akinori Kimura[SUP] 29 [/SUP], Seiya Imoto[SUP] 30 [/SUP], Satoru Miyano[SUP] 31 [/SUP], Seishi Ogawa[SUP] 32 [/SUP], Takanori Kanai[SUP] 33 [/SUP], Koichi Fukunaga[SUP] 1 [/SUP]
Affiliations
- PMID: 37441355
- PMCID: PMC10334380
- DOI: 10.1093/ofid/ofad311
Background: To determine the effectiveness of baricitinib in patients with coronavirus disease 2019 (COVID-19), investigate whether baricitinib prevents the need for invasive mechanical ventilation and identify patient subgroups that would benefit from baricitinib.
Methods: This observational matched-cohort study was conducted by the Japan COVID-19 Task Force, a nationwide multicenter consortium. Patients with COVID-19 aged ≥18 years were identified from 70 hospitals in Japan. Among patients with confirmed COVID-19 from February 2020 to September 2021, those receiving baricitinib were propensity-score matched with controls.
Results: Among 3309 patients, 144 propensity score-matched pairs were identified. Thirteen (9.0%) patients in the baricitinib group and 27 (18.8%) in the control group required invasive mechanical ventilation during the disease course (odds ratio, 0.43). Although the baricitinib group had more severe disease, there were no significant differences in the intensive care unit admission rates (odds ratio, 1.16) and mortality rates (odds ratio, 0.74) between groups. In subgroup analyses, baricitinib was associated with a significant reduction in the need for invasive mechanical ventilation in patients requiring oxygen support (odds ratio, 0.28), with rapid shadow spread on chest radiography (odds ratio, 0.11), or treated with remdesivir (odds ratio, 0.27), systemic corticosteroids (odds ratio, 0.31), or anticoagulants (odds ratio, 0.17).
Conclusions: Baricitinib is effective at preventing the need for invasive mechanical ventilation in patients with COVID-19.
Keywords: COVID-19; baricitinib; invasive mechanical ventilation; real-world data.