tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2023 May 17;10(5)
fad278.
doi: 10.1093/ofid/ofad278. eCollection 2023 May. Rapid Emergence of Potentially Transmissible Severe Acute Respiratory Syndrome Coronavirus 2 With Resistance to Combination Monoclonal Antibody Therapy
Jana L Jacobs[SUP] 1 [/SUP], Ghady Haidar[SUP] 1 [/SUP], Asma Naqvi[SUP] 1 [/SUP], Kevin D McCormick[SUP] 1 [/SUP], Michele Sobolewski[SUP] 1 [/SUP], Benjamin R Treat[SUP] 2 [/SUP], Amy L Heaps[SUP] 1 [/SUP], Jordan Simpson[SUP] 1 [/SUP], Kailey Hughes Kramer[SUP] 1 [/SUP], Erin McCreary[SUP] 1 [/SUP], J Ryan Bariola[SUP] 1 [/SUP], Cynthia Klamar-Blain[SUP] 1 [/SUP], Bernard J C Macatangay[SUP] 1 [/SUP], Dimiter Dimitrov[SUP] 1 [/SUP], Wei Li[SUP] 1 [/SUP], Christopher C Marino[SUP] 3 [/SUP], Anastasios Raptis[SUP] 3 [/SUP], Rahil Sethi[SUP] 4 [/SUP], Uma Chandran[SUP] 4 [/SUP], Simon Barratt-Boyes[SUP] 2 [/SUP], Urvi M Parikh[SUP] 1 [/SUP], John W Mellors[SUP] 1 [/SUP]
Affiliations
Prolonged coronavirus disease 2019 may generate new viral variants. We report an immunocompromised patient treated with monoclonal antibodies who experienced rebound of viral RNA and emergence of an antibody-resistant (>1000-fold) variant containing 5 mutations in the spike gene. The mutant virus was isolated from respiratory secretions, suggesting the potential for secondary transmission.
. 2023 May 17;10(5)
fad278.doi: 10.1093/ofid/ofad278. eCollection 2023 May. Rapid Emergence of Potentially Transmissible Severe Acute Respiratory Syndrome Coronavirus 2 With Resistance to Combination Monoclonal Antibody Therapy
Jana L Jacobs[SUP] 1 [/SUP], Ghady Haidar[SUP] 1 [/SUP], Asma Naqvi[SUP] 1 [/SUP], Kevin D McCormick[SUP] 1 [/SUP], Michele Sobolewski[SUP] 1 [/SUP], Benjamin R Treat[SUP] 2 [/SUP], Amy L Heaps[SUP] 1 [/SUP], Jordan Simpson[SUP] 1 [/SUP], Kailey Hughes Kramer[SUP] 1 [/SUP], Erin McCreary[SUP] 1 [/SUP], J Ryan Bariola[SUP] 1 [/SUP], Cynthia Klamar-Blain[SUP] 1 [/SUP], Bernard J C Macatangay[SUP] 1 [/SUP], Dimiter Dimitrov[SUP] 1 [/SUP], Wei Li[SUP] 1 [/SUP], Christopher C Marino[SUP] 3 [/SUP], Anastasios Raptis[SUP] 3 [/SUP], Rahil Sethi[SUP] 4 [/SUP], Uma Chandran[SUP] 4 [/SUP], Simon Barratt-Boyes[SUP] 2 [/SUP], Urvi M Parikh[SUP] 1 [/SUP], John W Mellors[SUP] 1 [/SUP]
Affiliations
- PMID: 37265667
- PMCID: PMC10230564
- DOI: 10.1093/ofid/ofad278
Prolonged coronavirus disease 2019 may generate new viral variants. We report an immunocompromised patient treated with monoclonal antibodies who experienced rebound of viral RNA and emergence of an antibody-resistant (>1000-fold) variant containing 5 mutations in the spike gene. The mutant virus was isolated from respiratory secretions, suggesting the potential for secondary transmission.