tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2023 Mar 28;10(5)
fad168.
doi: 10.1093/ofid/ofad168. eCollection 2023 May. Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Antibody Responses After Community Infections in Children and Adults
Fatimah S Dawood[SUP] 1 [/SUP], Alexia Couture[SUP] 1 [/SUP], Xueyan Zhang[SUP] 2 [/SUP], Melissa S Stockwell[SUP] 3 4 [/SUP], Christina A Porucznik[SUP] 5 [/SUP], Joseph B Stanford[SUP] 5 [/SUP], Marissa Hetrich[SUP] 2 [/SUP], Vic Veguilla[SUP] 1 [/SUP], Natalie Thornburg[SUP] 1 [/SUP], Christopher D Heaney[SUP] 2 [/SUP], Jing Wang[SUP] 1 [/SUP], Jazmin Duque[SUP] 6 [/SUP], Zuha Jeddy[SUP] 6 [/SUP], Maria Deloria Knoll[SUP] 2 [/SUP], Ruth Karron[SUP] 2 [/SUP]
Affiliations
Background: We compared postinfection severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibody (nAb) responses among children and adults while the D614G-like strain and Alpha, Iota, and Delta variants circulated.
Methods: During August 2020-October 2021, households with adults and children were enrolled and followed in Utah, New York City, and Maryland. Participants collected weekly respiratory swabs that were tested for SARS-CoV-2 and had sera collected during enrollment and follow-up. Sera were tested for SARS-CoV-2 nAb by pseudovirus assay. Postinfection titers were characterized with biexponential decay models.
Results: Eighty participants had SARS-CoV-2 infection during the study (47 with D614G-like virus, 17 with B.1.1.7, and 8 each with B.1.617.2 and B.1.526 virus). Homologous nAb geometric mean titers (GMTs) trended higher in adults (GMT = 2320) versus children 0-4 (GMT = 425, P = .33) and 5-17 years (GMT = 396, P = .31) at 1-5 weeks postinfection but were similar from 6 weeks. Timing of peak titers was similar by age. Results were consistent when participants with self-reported infection before enrollment were included (n = 178).
Conclusions: The SARS-CoV-2 nAb titers differed in children compared to adults early after infection but were similar by 6 weeks postinfection. If postvaccination nAb kinetics have similar trends, vaccine immunobridging studies may need to compare nAb responses in adults and children 6 weeks or more after vaccination.
Keywords: SARS-CoV-2; adults; antibodies; children.
. 2023 Mar 28;10(5)
fad168.doi: 10.1093/ofid/ofad168. eCollection 2023 May. Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Antibody Responses After Community Infections in Children and Adults
Fatimah S Dawood[SUP] 1 [/SUP], Alexia Couture[SUP] 1 [/SUP], Xueyan Zhang[SUP] 2 [/SUP], Melissa S Stockwell[SUP] 3 4 [/SUP], Christina A Porucznik[SUP] 5 [/SUP], Joseph B Stanford[SUP] 5 [/SUP], Marissa Hetrich[SUP] 2 [/SUP], Vic Veguilla[SUP] 1 [/SUP], Natalie Thornburg[SUP] 1 [/SUP], Christopher D Heaney[SUP] 2 [/SUP], Jing Wang[SUP] 1 [/SUP], Jazmin Duque[SUP] 6 [/SUP], Zuha Jeddy[SUP] 6 [/SUP], Maria Deloria Knoll[SUP] 2 [/SUP], Ruth Karron[SUP] 2 [/SUP]
Affiliations
- PMID: 37213425
- PMCID: PMC10199115 (available on 2024-03-28)
- DOI: 10.1093/ofid/ofad168
Background: We compared postinfection severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibody (nAb) responses among children and adults while the D614G-like strain and Alpha, Iota, and Delta variants circulated.
Methods: During August 2020-October 2021, households with adults and children were enrolled and followed in Utah, New York City, and Maryland. Participants collected weekly respiratory swabs that were tested for SARS-CoV-2 and had sera collected during enrollment and follow-up. Sera were tested for SARS-CoV-2 nAb by pseudovirus assay. Postinfection titers were characterized with biexponential decay models.
Results: Eighty participants had SARS-CoV-2 infection during the study (47 with D614G-like virus, 17 with B.1.1.7, and 8 each with B.1.617.2 and B.1.526 virus). Homologous nAb geometric mean titers (GMTs) trended higher in adults (GMT = 2320) versus children 0-4 (GMT = 425, P = .33) and 5-17 years (GMT = 396, P = .31) at 1-5 weeks postinfection but were similar from 6 weeks. Timing of peak titers was similar by age. Results were consistent when participants with self-reported infection before enrollment were included (n = 178).
Conclusions: The SARS-CoV-2 nAb titers differed in children compared to adults early after infection but were similar by 6 weeks postinfection. If postvaccination nAb kinetics have similar trends, vaccine immunobridging studies may need to compare nAb responses in adults and children 6 weeks or more after vaccination.
Keywords: SARS-CoV-2; adults; antibodies; children.