tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2023 Apr 6;10(4)
fad189.
doi: 10.1093/ofid/ofad189. eCollection 2023 Apr.
Successful Treatment of Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Patients With Immunodeficiency With Extended Nirmatrelvir/Ritonavir: Case Series
Madison Breeden[SUP] 1 [/SUP], Samuel L Aitken[SUP] 2 3 [/SUP], Ji Hoon Baang[SUP] 1 [/SUP], Misty Gravelin[SUP] 4 [/SUP], Daniel R Kaul[SUP] 1 [/SUP], Adam S Lauring[SUP] 1 [/SUP], Lindsay A Petty[SUP] 1 [/SUP], Kevin S Gregg[SUP] 1 [/SUP]
Affiliations
Abstract
Immunocompromised patients with B-cell deficiencies are at risk for prolonged symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We describe 4 patients treated for B-cell malignancies with B-cell-depleting therapies who developed persistent SARS-CoV-2 infection and had resolution of symptoms following an extended course of nirmatrelvir/ritonavir.
Keywords: SARS-CoV-2; immunodeficiency; prolonged infection.
. 2023 Apr 6;10(4)
fad189.doi: 10.1093/ofid/ofad189. eCollection 2023 Apr.
Successful Treatment of Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Patients With Immunodeficiency With Extended Nirmatrelvir/Ritonavir: Case Series
Madison Breeden[SUP] 1 [/SUP], Samuel L Aitken[SUP] 2 3 [/SUP], Ji Hoon Baang[SUP] 1 [/SUP], Misty Gravelin[SUP] 4 [/SUP], Daniel R Kaul[SUP] 1 [/SUP], Adam S Lauring[SUP] 1 [/SUP], Lindsay A Petty[SUP] 1 [/SUP], Kevin S Gregg[SUP] 1 [/SUP]
Affiliations
- PMID: 37089775
- PMCID: PMC10114524
- DOI: 10.1093/ofid/ofad189
Abstract
Immunocompromised patients with B-cell deficiencies are at risk for prolonged symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We describe 4 patients treated for B-cell malignancies with B-cell-depleting therapies who developed persistent SARS-CoV-2 infection and had resolution of symptoms following an extended course of nirmatrelvir/ritonavir.
Keywords: SARS-CoV-2; immunodeficiency; prolonged infection.