tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2021 Apr 17;8(8)
fab153.
doi: 10.1093/ofid/ofab153. eCollection 2021 Aug.
Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals With Coronavirus Disease 2019
James Regan[SUP] 1 [/SUP], James P Flynn[SUP] 1 [/SUP], Alexandra Rosenthal[SUP] 1 [/SUP], Hannah Jordan[SUP] 1 [/SUP], Yijia Li[SUP] 1 [/SUP], Rida Chishti[SUP] 1 [/SUP], Francoise Giguel[SUP] 2 [/SUP], Heather Corry[SUP] 1 [/SUP], Kendyll Coxen[SUP] 1 [/SUP], Jesse Fajnzylber[SUP] 1 [/SUP], Elizabeth Gillespie[SUP] 1 [/SUP], Daniel R Kuritzkes[SUP] 1 [/SUP], Nir Hacohen[SUP] 2 3 [/SUP], Marcia B Goldberg[SUP] 2 3 [/SUP], Michael R Filbin[SUP] 2 3 [/SUP], Xu G Yu[SUP] 1 2 4 [/SUP], Lindsey Baden[SUP] 1 [/SUP], Ruy M Ribeiro[SUP] 5 [/SUP], Alan S Perelson[SUP] 5 6 [/SUP], Jessica M Conway[SUP] 7 [/SUP], Jonathan Z Li[SUP] 1 [/SUP], MGH COVID-19 Collection & Processing Teams
Collaborators, Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) kinetics remain understudied, including the impact of remdesivir. In hospitalized individuals, peak sputum viral load occurred in week 2 of symptoms, whereas viremia peaked within 1 week of symptom-onset, suggesting early systemic seeding of SARS-CoV-2. Remdesivir treatment was associated with faster viral decay.
Keywords: COVID-19; SARS-CoV-2; remdesivir; viral kinetics; viral load.
. 2021 Apr 17;8(8)
fab153.doi: 10.1093/ofid/ofab153. eCollection 2021 Aug.
Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals With Coronavirus Disease 2019
James Regan[SUP] 1 [/SUP], James P Flynn[SUP] 1 [/SUP], Alexandra Rosenthal[SUP] 1 [/SUP], Hannah Jordan[SUP] 1 [/SUP], Yijia Li[SUP] 1 [/SUP], Rida Chishti[SUP] 1 [/SUP], Francoise Giguel[SUP] 2 [/SUP], Heather Corry[SUP] 1 [/SUP], Kendyll Coxen[SUP] 1 [/SUP], Jesse Fajnzylber[SUP] 1 [/SUP], Elizabeth Gillespie[SUP] 1 [/SUP], Daniel R Kuritzkes[SUP] 1 [/SUP], Nir Hacohen[SUP] 2 3 [/SUP], Marcia B Goldberg[SUP] 2 3 [/SUP], Michael R Filbin[SUP] 2 3 [/SUP], Xu G Yu[SUP] 1 2 4 [/SUP], Lindsey Baden[SUP] 1 [/SUP], Ruy M Ribeiro[SUP] 5 [/SUP], Alan S Perelson[SUP] 5 6 [/SUP], Jessica M Conway[SUP] 7 [/SUP], Jonathan Z Li[SUP] 1 [/SUP], MGH COVID-19 Collection & Processing Teams
Collaborators, Affiliations
- PMID: 34430669
- PMCID: PMC8083268
- DOI: 10.1093/ofid/ofab153
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) kinetics remain understudied, including the impact of remdesivir. In hospitalized individuals, peak sputum viral load occurred in week 2 of symptoms, whereas viremia peaked within 1 week of symptom-onset, suggesting early systemic seeding of SARS-CoV-2. Remdesivir treatment was associated with faster viral decay.
Keywords: COVID-19; SARS-CoV-2; remdesivir; viral kinetics; viral load.