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Open Forum Infect Dis . Yield of Severe Acute Respiratory Syndrome Coronavirus 2 Lower Respiratory Tract Testing After a Negative Nasopharyngeal Tes

tetano

Editor, Senior Moderator
Open Forum Infect Dis


. 2021 May 19;8(6):ofab257.
doi: 10.1093/ofid/ofab257. eCollection 2021 Jun.
Yield of Severe Acute Respiratory Syndrome Coronavirus 2 Lower Respiratory Tract Testing After a Negative Nasopharyngeal Test Among Hospitalized Persons Under Investigation for Coronavirus Disease 2019


Kenechukwu Egbuonu[SUP] 1 [/SUP], Emily P Hyle[SUP] 2 3 4 [/SUP], Rocio M Hurtado[SUP] 3 4 5 [/SUP], George A Alba[SUP] 4 6 [/SUP], Kimon C Zachary[SUP] 3 4 7 [/SUP], John A Branda[SUP] 4 8 [/SUP], Kathryn A Hibbert[SUP] 4 6 [/SUP], David C Hooper[SUP] 3 4 7 [/SUP], Erica S Shenoy[SUP] 3 4 7 [/SUP], Sarah E Turbett[SUP] 3 4 8 [/SUP], Caitlin M Dugdale[SUP] 2 3 4 [/SUP]



Affiliations

Abstract

Among hospitalized persons under investigation for coronavirus disease 2019 (COVID-19), more repeated severe acute respiratory syndrome coronavirus 2 nucleic acid amplification tests (NAATs) after a negative NAAT were positive from lower than from upper respiratory tract specimens (1.9% vs 1.0%, P = .033). Lower respiratory testing should be prioritized among patients displaying respiratory symptoms with moderate-to-high suspicion for COVID-19 after 1 negative upper respiratory NAAT.

Keywords: COVID-19 testing; coronavirus; lower respiratory tract.
 
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