tetano
Editor, Senior Moderator
Open Heart
. 2023 Feb;10(1):e002192.
doi: 10.1136/openhrt-2022-002192.
Adjudicated myocarditis and multisystem illness trajectory in healthcare workers post-COVID-19
Robert Sykes[SUP] 1 2 [/SUP], Andrew J Morrow[SUP] 1 3 [/SUP], Alex McConnachie[SUP] 4 [/SUP], Anna Kamdar[SUP] 1 [/SUP], C Bagot[SUP] 5 [/SUP], Hannah Bayes[SUP] 6 [/SUP], Kevin G Blyth[SUP] 7 8 [/SUP], Michael Briscoe[SUP] 3 [/SUP], Heeraj Bulluck[SUP] 9 [/SUP], David Carrick[SUP] 10 [/SUP], Colin Church[SUP] 1 11 [/SUP], David Corcoran[SUP] 3 [/SUP], C Delles[SUP] 1 [/SUP], Iain Findlay[SUP] 12 [/SUP], Vivienne B Gibson[SUP] 13 [/SUP], Lynsey Gillespie[SUP] 14 [/SUP], Douglas Grieve[SUP] 15 [/SUP], Pauline Hall Barrientos[SUP] 16 [/SUP], Antonia Ho[SUP] 17 [/SUP], N N Lang[SUP] 1 3 [/SUP], David J Lowe[SUP] 18 [/SUP], Vera Lennie[SUP] 19 [/SUP], Peter MacFarlane[SUP] 1 [/SUP], Kaithlin J Mayne[SUP] 1 [/SUP], Patrick Mark[SUP] 1 [/SUP], Alasdair McIntosh[SUP] 4 [/SUP], Ross McGeoch[SUP] 10 [/SUP], Christopher McGinley[SUP] 3 [/SUP], Connor Mckee[SUP] 3 [/SUP], Sabrina Nordin[SUP] 3 [/SUP], Alexander Payne[SUP] 20 [/SUP], Alastair Rankin[SUP] 1 [/SUP], Keith E Robertson[SUP] 2 [/SUP], Nicola Ryan[SUP] 19 [/SUP], Giles H Roditi[SUP] 21 [/SUP], Naveed Sattar[SUP] 1 [/SUP], David B Stobo[SUP] 21 [/SUP], Sarah Allwood-Spiers[SUP] 8 [/SUP], Rhian Touyz[SUP] 1 [/SUP], Gruschen Veldtman[SUP] 2 [/SUP], Sarah Weeden[SUP] 4 [/SUP], Stuart Watkins[SUP] 2 [/SUP], Paul Welsh[SUP] 1 [/SUP], Ryan Wereski[SUP] 22 [/SUP], Kenneth Mangion[SUP] 1 3 [/SUP], Colin Berry[SUP] 23 2 3 [/SUP]
Affiliations
Abstract
Background: We investigated the associations of healthcare worker status with multisystem illness trajectory in hospitalised post-COVID-19 individuals.
Methods and results: One hundred and sixty-eight patients were evaluated 28-60 days after the last episode of hospital care. Thirty-six (21%) were healthcare workers. Compared with non-healthcare workers, healthcare workers were of similar age (51.3 (8.7) years vs 55.0 (12.4) years; p=0.09) more often women (26 (72%) vs 48 (38%); p<0.01) and had lower 10-year cardiovascular risk (%) (8.1 (7.9) vs 15.0 (11.5); p<0.01) and Coronavirus Clinical Characterisation Consortium in-hospital mortality risk (7.3 (10.2) vs 12.7 (9.8); p<0.01). Healthcare worker status associated with less acute inflammation (peak C reactive protein 48 mg/L (IQR: 14-165) vs 112 mg/L (52-181)), milder illness reflected by WHO clinical severity score distribution (p=0.04) and shorter duration of admission (4 days (IQR: 2-6) vs 6 days (3-12)).In adjusted multivariate logistic regression analysis, healthcare worker status associated with a binary classification (probable/very likely vs not present/unlikely) of adjudicated myocarditis (OR: 2.99; 95% CI (1.01 to 8.89) by 28-60 days postdischarge).After a mean (SD, range) duration of follow-up after hospital discharge of 450 (88) days (range 290, 627 days), fewer healthcare workers died or were rehospitalised (1 (3%) vs 22 (17%); p=0.038) and secondary care referrals for post-COVID-19 syndrome were common (42%) and similar to non-healthcare workers (38%; p=0.934).
Conclusion: Healthcare worker status was independently associated with the likelihood of adjudicated myocarditis, despite better antecedent health. Two in five healthcare workers had a secondary care referral for post-COVID-19 syndrome.
Trial registration number: NCT04403607.
Keywords: COVID-19; Magnetic Resonance Imaging; Myocarditis; Risk Factors.
. 2023 Feb;10(1):e002192.
doi: 10.1136/openhrt-2022-002192.
Adjudicated myocarditis and multisystem illness trajectory in healthcare workers post-COVID-19
Robert Sykes[SUP] 1 2 [/SUP], Andrew J Morrow[SUP] 1 3 [/SUP], Alex McConnachie[SUP] 4 [/SUP], Anna Kamdar[SUP] 1 [/SUP], C Bagot[SUP] 5 [/SUP], Hannah Bayes[SUP] 6 [/SUP], Kevin G Blyth[SUP] 7 8 [/SUP], Michael Briscoe[SUP] 3 [/SUP], Heeraj Bulluck[SUP] 9 [/SUP], David Carrick[SUP] 10 [/SUP], Colin Church[SUP] 1 11 [/SUP], David Corcoran[SUP] 3 [/SUP], C Delles[SUP] 1 [/SUP], Iain Findlay[SUP] 12 [/SUP], Vivienne B Gibson[SUP] 13 [/SUP], Lynsey Gillespie[SUP] 14 [/SUP], Douglas Grieve[SUP] 15 [/SUP], Pauline Hall Barrientos[SUP] 16 [/SUP], Antonia Ho[SUP] 17 [/SUP], N N Lang[SUP] 1 3 [/SUP], David J Lowe[SUP] 18 [/SUP], Vera Lennie[SUP] 19 [/SUP], Peter MacFarlane[SUP] 1 [/SUP], Kaithlin J Mayne[SUP] 1 [/SUP], Patrick Mark[SUP] 1 [/SUP], Alasdair McIntosh[SUP] 4 [/SUP], Ross McGeoch[SUP] 10 [/SUP], Christopher McGinley[SUP] 3 [/SUP], Connor Mckee[SUP] 3 [/SUP], Sabrina Nordin[SUP] 3 [/SUP], Alexander Payne[SUP] 20 [/SUP], Alastair Rankin[SUP] 1 [/SUP], Keith E Robertson[SUP] 2 [/SUP], Nicola Ryan[SUP] 19 [/SUP], Giles H Roditi[SUP] 21 [/SUP], Naveed Sattar[SUP] 1 [/SUP], David B Stobo[SUP] 21 [/SUP], Sarah Allwood-Spiers[SUP] 8 [/SUP], Rhian Touyz[SUP] 1 [/SUP], Gruschen Veldtman[SUP] 2 [/SUP], Sarah Weeden[SUP] 4 [/SUP], Stuart Watkins[SUP] 2 [/SUP], Paul Welsh[SUP] 1 [/SUP], Ryan Wereski[SUP] 22 [/SUP], Kenneth Mangion[SUP] 1 3 [/SUP], Colin Berry[SUP] 23 2 3 [/SUP]
Affiliations
- PMID: 36822817
- DOI: 10.1136/openhrt-2022-002192
Abstract
Background: We investigated the associations of healthcare worker status with multisystem illness trajectory in hospitalised post-COVID-19 individuals.
Methods and results: One hundred and sixty-eight patients were evaluated 28-60 days after the last episode of hospital care. Thirty-six (21%) were healthcare workers. Compared with non-healthcare workers, healthcare workers were of similar age (51.3 (8.7) years vs 55.0 (12.4) years; p=0.09) more often women (26 (72%) vs 48 (38%); p<0.01) and had lower 10-year cardiovascular risk (%) (8.1 (7.9) vs 15.0 (11.5); p<0.01) and Coronavirus Clinical Characterisation Consortium in-hospital mortality risk (7.3 (10.2) vs 12.7 (9.8); p<0.01). Healthcare worker status associated with less acute inflammation (peak C reactive protein 48 mg/L (IQR: 14-165) vs 112 mg/L (52-181)), milder illness reflected by WHO clinical severity score distribution (p=0.04) and shorter duration of admission (4 days (IQR: 2-6) vs 6 days (3-12)).In adjusted multivariate logistic regression analysis, healthcare worker status associated with a binary classification (probable/very likely vs not present/unlikely) of adjudicated myocarditis (OR: 2.99; 95% CI (1.01 to 8.89) by 28-60 days postdischarge).After a mean (SD, range) duration of follow-up after hospital discharge of 450 (88) days (range 290, 627 days), fewer healthcare workers died or were rehospitalised (1 (3%) vs 22 (17%); p=0.038) and secondary care referrals for post-COVID-19 syndrome were common (42%) and similar to non-healthcare workers (38%; p=0.934).
Conclusion: Healthcare worker status was independently associated with the likelihood of adjudicated myocarditis, despite better antecedent health. Two in five healthcare workers had a secondary care referral for post-COVID-19 syndrome.
Trial registration number: NCT04403607.
Keywords: COVID-19; Magnetic Resonance Imaging; Myocarditis; Risk Factors.