tetano
Editor, Senior Moderator
Acta Pol Pharm. 2012 Nov-Dec;69(6):1218-23.
Oseltamivir analog with boron cluster modulator.
Adamska A, Olejniczak AB, Zwoliński K, Szczepek WJ, Kr?l E, Szewczyk B, Grynkiewicz G, Leśnikowski ZJ.
Source
Institute of Medical Biology, Polish Academy of Sciences, Ł?dź, Poland.
Abstract
Synthesis of novel neuraminidase inhibitor -- carborane ester of oseltamivir carboxylic acid is described, and its physicochemical and spectral characteristics is provided. Surprisingly, carborane analog of oseltamivir is of an order of magnitude less active than its precursor, the corresponding ethyl ester, which is the active principle of pharmaceutical preparations used in influenza prophylactics and therapy.
PMID:
23285684
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/23285684
Oseltamivir analog with boron cluster modulator.
Adamska A, Olejniczak AB, Zwoliński K, Szczepek WJ, Kr?l E, Szewczyk B, Grynkiewicz G, Leśnikowski ZJ.
Source
Institute of Medical Biology, Polish Academy of Sciences, Ł?dź, Poland.
Abstract
Synthesis of novel neuraminidase inhibitor -- carborane ester of oseltamivir carboxylic acid is described, and its physicochemical and spectral characteristics is provided. Surprisingly, carborane analog of oseltamivir is of an order of magnitude less active than its precursor, the corresponding ethyl ester, which is the active principle of pharmaceutical preparations used in influenza prophylactics and therapy.
PMID:
23285684
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/23285684