tetano
Editor, Senior Moderator
Semin Perinatol. 2014 Sep 30. pii: S0146-0005(14)00103-7. doi: 10.1053/j.semperi.2014.08.015. [Epub ahead of print]
Oseltamivir for influenza in pregnancy.
Beigi RH1, Venkataramanan R2, Caritis SN3.
Author information
Abstract
Pregnancy predisposes women to disproportionate morbidity and mortality from influenza infections. This is true for both seasonal epidemics as well as occasional pandemics. Inactivated yearly influenza vaccines are the best available method of disease prevention and are recommended for all pregnant women in any trimester of pregnancy and postpartum. Oseltamivir (Tamiflu?) is currently the first-line recommended and most commonly used pharmaceutical agent for influenza prophylaxis and treatment. Oseltamivir has been demonstrated to prevent disease among exposed individuals, as well as to shorten the duration of illness and lessen the likelihood of complications among those infected. The physiologic adaptations of pregnancy may alter the pharmacokinetics and pharmacodynamics of this important drug. Updated evidence regarding these potential alterations, current knowledge gaps, and future investigative directions is discussed.
Copyright ? 2014 Elsevier Inc. All rights reserved.
KEYWORDS:
Influenza; Oseltamivir; Pharmacology; Pregnancy
PMID:
25281358
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25281358
Oseltamivir for influenza in pregnancy.
Beigi RH1, Venkataramanan R2, Caritis SN3.
Author information
Abstract
Pregnancy predisposes women to disproportionate morbidity and mortality from influenza infections. This is true for both seasonal epidemics as well as occasional pandemics. Inactivated yearly influenza vaccines are the best available method of disease prevention and are recommended for all pregnant women in any trimester of pregnancy and postpartum. Oseltamivir (Tamiflu?) is currently the first-line recommended and most commonly used pharmaceutical agent for influenza prophylaxis and treatment. Oseltamivir has been demonstrated to prevent disease among exposed individuals, as well as to shorten the duration of illness and lessen the likelihood of complications among those infected. The physiologic adaptations of pregnancy may alter the pharmacokinetics and pharmacodynamics of this important drug. Updated evidence regarding these potential alterations, current knowledge gaps, and future investigative directions is discussed.
Copyright ? 2014 Elsevier Inc. All rights reserved.
KEYWORDS:
Influenza; Oseltamivir; Pharmacology; Pregnancy
PMID:
25281358
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25281358