tetano
Editor, Senior Moderator
Haematologica. 2011 May 5. [Epub ahead of print]
Outcome of pandemic H1N1 infections in hematopoietic stem cell transplant recipients.
Ljungman P, de la Camara R, Perez-Bercoff L, Abecasis M, Nieto Campuzano JB, Cannata-Ortiz J, Cordonnier C, Einsele H, Gonzalez-Vincent M, Espigado I, Halter J, Martino R, Mohty B, Sucak G, Ullmann AJ, Vasques L, Ward KN, Engelhard D.
Source
Stockholm, Sweden;
Abstract
During 2009, a new strain of A/H1N1 influenza appeared and became pandemic. A prospective study was performed to collect data regarding risk factors and outcome of A/H1N1 in haematopoietic stem cell transplant recipients. Only verified pandemic A/H1N1 influenza strains were included. 286 patients were reported; 222 allogeneic and 64 autologous recipients. The median age was 38.3 years and the median time from transplant was 19.4 months. 267 patients were given oseltamivir and 15 zanamivir. 125 patients (43.7%) were hospitalized. 93 (32.5%) developed lower respiratory tract disease. In multivariate analysis, risk factors were age (OR 1.025; 1.01-1.04; p =.002) and lymphopenia (OR 2.49; 1.33-4.67; p<.001). 33 patients (11.5 %) required mechanical ventilation. 18 patients (6.3%) died from A/H1N1 infection or its complications. Neutropenia (p=.03) and patient age (p=.04) were significant risk factors for death. The 2009 A/H1N1 influenza pandemic caused severe complications in stem cell transplant recipients.
PMID:
21546495
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21546495
Outcome of pandemic H1N1 infections in hematopoietic stem cell transplant recipients.
Ljungman P, de la Camara R, Perez-Bercoff L, Abecasis M, Nieto Campuzano JB, Cannata-Ortiz J, Cordonnier C, Einsele H, Gonzalez-Vincent M, Espigado I, Halter J, Martino R, Mohty B, Sucak G, Ullmann AJ, Vasques L, Ward KN, Engelhard D.
Source
Stockholm, Sweden;
Abstract
During 2009, a new strain of A/H1N1 influenza appeared and became pandemic. A prospective study was performed to collect data regarding risk factors and outcome of A/H1N1 in haematopoietic stem cell transplant recipients. Only verified pandemic A/H1N1 influenza strains were included. 286 patients were reported; 222 allogeneic and 64 autologous recipients. The median age was 38.3 years and the median time from transplant was 19.4 months. 267 patients were given oseltamivir and 15 zanamivir. 125 patients (43.7%) were hospitalized. 93 (32.5%) developed lower respiratory tract disease. In multivariate analysis, risk factors were age (OR 1.025; 1.01-1.04; p =.002) and lymphopenia (OR 2.49; 1.33-4.67; p<.001). 33 patients (11.5 %) required mechanical ventilation. 18 patients (6.3%) died from A/H1N1 infection or its complications. Neutropenia (p=.03) and patient age (p=.04) were significant risk factors for death. The 2009 A/H1N1 influenza pandemic caused severe complications in stem cell transplant recipients.
PMID:
21546495
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21546495