tetano
Editor, Senior Moderator
J Am Geriatr Soc. 2012 Mar 29. doi: 10.1111/j.1532-5415.2012.03903.x. [Epub ahead of print]
Pandemic 2009 A(H1N1) Infection Requiring Hospitalization of Elderly Spanish Adults.
Pa?o-Pardo JR, Viasus D, Pach?n J, Campins A, L?pez-Medrano F, Villoslada A, Guti?rrez-Cuadra M, Pumarola T, Del Toro MD, Oteo JA, Mart?nez-Montauti J, Guti?rrez-Aroca J, Segura F, Carratal? J; for the Novel Influenza A (H1N1) Study Group of the Spanish Network for Research in Infectious Diseases.
Source
Infectious Diseases Unit, Hospital Universitario La Paz-IDIPAZ, Madrid.
Abstract
OBJECTIVES:
To describe the clinical presentation and prognosis of elderly adults hospitalized with pandemic 2009 A(H1N1) influenza infection and to compare these data with those of younger patients.
DESIGN:
Prospective, observational, multicenter study.
SETTING:
Thirteen hospitals in Spain.
PARTICIPANTS:
Adults admitted to the hospital with confirmed pandemic 2009 A(H1N1) influenza infection.
MEASUREMENTS:
Demographic, clinical, laboratory, radiological, and outcome variables.
RESULTS:
Between June 12 and November 10, 2009, 585 adults with confirmed 2009 A(H1N1) influenza were hospitalized, of whom 50 (8.5%) were aged 65 and older (median age 72, range 65-87). Older adults (≥65) were more likely to have associated comorbidities (88.0% vs 51.2%; P < .001), primarily chronic pulmonary diseases (46.0% vs 27.3%; P < .001). Lower respiratory tract symptoms and signs such as dyspnea (60.0% vs 45.6%) and wheezing (46.0% vs 27.8%; P = .007) were also more common in these elderly adults, although pulmonary infiltrates were present in just 14 (28.0%) of the older adults, compared with 221 (41.3%) of the younger adults (P = .06). Multilobar involvement was less frequent in elderly adults with pulmonary infiltrates than younger adults with pulmonary infiltrates (21.4% vs 60.0%; P = .05). Rhinorrhea (4.0% vs 21.9%; P = .003), myalgias (42.0% vs 59.1%; P = .01), and sore throat (14.0% vs 29.2%; P = .02) were more frequent in younger adults. Early antiviral therapy (<48 hours) was similar in the two groups (34.0% vs 37.9%; P = .58). Two older adults (4.0%) died during hospitalization, compared with 11 (2.1%) younger adults (P = .30).
CONCLUSION:
Elderly adults with 2009 A(H1N1) influenza had fewer viral-like upper respiratory symptoms than did younger adults. Pneumonia was more frequent in younger adults. No significant differences were observed in hospital mortality.
? 2012, Copyright the Authors Journal compilation ? 2012, The American Geriatrics Society.
PMID:
22462803
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22462803
Pandemic 2009 A(H1N1) Infection Requiring Hospitalization of Elderly Spanish Adults.
Pa?o-Pardo JR, Viasus D, Pach?n J, Campins A, L?pez-Medrano F, Villoslada A, Guti?rrez-Cuadra M, Pumarola T, Del Toro MD, Oteo JA, Mart?nez-Montauti J, Guti?rrez-Aroca J, Segura F, Carratal? J; for the Novel Influenza A (H1N1) Study Group of the Spanish Network for Research in Infectious Diseases.
Source
Infectious Diseases Unit, Hospital Universitario La Paz-IDIPAZ, Madrid.
Abstract
OBJECTIVES:
To describe the clinical presentation and prognosis of elderly adults hospitalized with pandemic 2009 A(H1N1) influenza infection and to compare these data with those of younger patients.
DESIGN:
Prospective, observational, multicenter study.
SETTING:
Thirteen hospitals in Spain.
PARTICIPANTS:
Adults admitted to the hospital with confirmed pandemic 2009 A(H1N1) influenza infection.
MEASUREMENTS:
Demographic, clinical, laboratory, radiological, and outcome variables.
RESULTS:
Between June 12 and November 10, 2009, 585 adults with confirmed 2009 A(H1N1) influenza were hospitalized, of whom 50 (8.5%) were aged 65 and older (median age 72, range 65-87). Older adults (≥65) were more likely to have associated comorbidities (88.0% vs 51.2%; P < .001), primarily chronic pulmonary diseases (46.0% vs 27.3%; P < .001). Lower respiratory tract symptoms and signs such as dyspnea (60.0% vs 45.6%) and wheezing (46.0% vs 27.8%; P = .007) were also more common in these elderly adults, although pulmonary infiltrates were present in just 14 (28.0%) of the older adults, compared with 221 (41.3%) of the younger adults (P = .06). Multilobar involvement was less frequent in elderly adults with pulmonary infiltrates than younger adults with pulmonary infiltrates (21.4% vs 60.0%; P = .05). Rhinorrhea (4.0% vs 21.9%; P = .003), myalgias (42.0% vs 59.1%; P = .01), and sore throat (14.0% vs 29.2%; P = .02) were more frequent in younger adults. Early antiviral therapy (<48 hours) was similar in the two groups (34.0% vs 37.9%; P = .58). Two older adults (4.0%) died during hospitalization, compared with 11 (2.1%) younger adults (P = .30).
CONCLUSION:
Elderly adults with 2009 A(H1N1) influenza had fewer viral-like upper respiratory symptoms than did younger adults. Pneumonia was more frequent in younger adults. No significant differences were observed in hospital mortality.
? 2012, Copyright the Authors Journal compilation ? 2012, The American Geriatrics Society.
PMID:
22462803
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22462803