tetano
Editor, Senior Moderator
J Virol. 2012 Nov 28. [Epub ahead of print]
Pandemic 2009 H1N1 influenza A virus carrying a Q136K mutation in the neuraminidase gene is resistant to zanamivir but exhibits reduced fitness in the guinea pig transmission model.
Kaminski MM, Ohnemus A, Staeheli P, Rubbenstroth D.
Source
Department of Virology, University of Freiburg, Hermann-Herder-Str. 11, D-79104 Freiburg, Germany.
Abstract
Resistance of influenza A viruses to neuraminidase inhibitors can arise through mutations in the neuraminidase (NA) gene. We show here that a Q136K mutation in the NA of the 2009 pandemic H1N1 virus confers a high degree of resistance to zanamivir. Resistance is accompanied by reduced amounts of NA molecules in viral particles and reduced intrinsic enzymatic activity of mutant NA. Interestingly, the Q136K mutation strongly impairs viral fitness in the guinea pig transmission model.
PMID:
23192869
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23192869
Pandemic 2009 H1N1 influenza A virus carrying a Q136K mutation in the neuraminidase gene is resistant to zanamivir but exhibits reduced fitness in the guinea pig transmission model.
Kaminski MM, Ohnemus A, Staeheli P, Rubbenstroth D.
Source
Department of Virology, University of Freiburg, Hermann-Herder-Str. 11, D-79104 Freiburg, Germany.
Abstract
Resistance of influenza A viruses to neuraminidase inhibitors can arise through mutations in the neuraminidase (NA) gene. We show here that a Q136K mutation in the NA of the 2009 pandemic H1N1 virus confers a high degree of resistance to zanamivir. Resistance is accompanied by reduced amounts of NA molecules in viral particles and reduced intrinsic enzymatic activity of mutant NA. Interestingly, the Q136K mutation strongly impairs viral fitness in the guinea pig transmission model.
PMID:
23192869
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23192869