tetano
Editor, Senior Moderator
The world has recently overcome the first influenza pandemic of the 21st century caused by a novel H1N1 virus (pH1N1) which is a triple reassortant comprising genes derived from avian, human, and swine viruses and antigenically quite different from seasonal H1N1 strains. Although the case fatality rates have decreased in many developed countries, the situation is still alarming in many developing countries including India where considerable numbers of new cases are appearing everyday.
There is still a high morbidity and mortality of susceptible adult as well as young population without having underlying health issues due to the influenza infection.
Results: To achieve a better understanding of the risk posed by the pH1N1 and to understand its pathogenicity, we studied the host gene expression response to Indian isolate of pH1N1 infection and compared it with seasonal H1N1 infection. The response was studied at four different time points (4, 8, 16 and 24h) post infection (hpi) in A549 cells using microarray platform.
We found that pH1N1 induces immune response earlier than seasonal H1N1 viruses, but at the later stages of infection there is a suppression of host immune responses. The infection with pH1N1 resulted in considerable decrease in the expression of cytokine and other immune genes namely IL8, STAT1, B2M and IL4 compared to seasonal H1N1.
Conclusion: We propose that the inability to induce strong innate immune response could be a reason for the high transmissibility, pathogenicity and mortality caused by pH1N1 virus.
Author: Sanjay MukherjeeVeena VipatAkhilesh MishraShailesh PawarAlok Chakrabarti
Credits/Source: Virology Journal 2011, 8:140
http://7thspace.com/headlines/37693...sible_mechanism_of_high_transmissibility.html
There is still a high morbidity and mortality of susceptible adult as well as young population without having underlying health issues due to the influenza infection.
Results: To achieve a better understanding of the risk posed by the pH1N1 and to understand its pathogenicity, we studied the host gene expression response to Indian isolate of pH1N1 infection and compared it with seasonal H1N1 infection. The response was studied at four different time points (4, 8, 16 and 24h) post infection (hpi) in A549 cells using microarray platform.
We found that pH1N1 induces immune response earlier than seasonal H1N1 viruses, but at the later stages of infection there is a suppression of host immune responses. The infection with pH1N1 resulted in considerable decrease in the expression of cytokine and other immune genes namely IL8, STAT1, B2M and IL4 compared to seasonal H1N1.
Conclusion: We propose that the inability to induce strong innate immune response could be a reason for the high transmissibility, pathogenicity and mortality caused by pH1N1 virus.
Author: Sanjay MukherjeeVeena VipatAkhilesh MishraShailesh PawarAlok Chakrabarti
Credits/Source: Virology Journal 2011, 8:140
http://7thspace.com/headlines/37693...sible_mechanism_of_high_transmissibility.html