tetano
Editor, Senior Moderator
J Acquir Immune Defic Syndr. 2010 Nov 13. [Epub ahead of print]
Pandemic (H1N1) 2009 Influenza Virus Seroconversion Rates in HIV-infected Individuals.
Kok J, Tudo K, Blyth CC, Foo H, Hueston L, Dwyer DE.
1Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales 2145, Australia; 2School of Paediatrics and Child Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Western Australia, Princess Margaret Hospital, Subiaco, Western Australia 6008, Australia; and 3Department of Infectious Diseases, Wollongong Hospital, Wollongong, New South Wales 2500, Australia.
Abstract
The impact of pandemic (H1N1) 2009 influenza in HIV-infected individuals is unknown. Determining the prevalence of pandemic influenza in this at-risk group will guide vaccination programs. Following the first pandemic wave, the seroprevalence rate of pandemic influenza in HIV-infected individuals in western Sydney, New South Wales, Australia was 34.2%, similar to the rate observed in the general population. However, true seroprevalence is more accurately determined by seroconversion, defined as a four-fold or greater rise between pre- and post-exposure antibody levels, which was 14.6% in the present study. Seroconversion rates were independent of CD4+ T-lymphocyte count and HIV plasma load. Neither HIV infection, nor severe immunosuppression, was a significant risk factor for pandemic influenza during the first southern hemisphere pandemic wave.
PMID: 21084991 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21084991
Pandemic (H1N1) 2009 Influenza Virus Seroconversion Rates in HIV-infected Individuals.
Kok J, Tudo K, Blyth CC, Foo H, Hueston L, Dwyer DE.
1Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales 2145, Australia; 2School of Paediatrics and Child Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Western Australia, Princess Margaret Hospital, Subiaco, Western Australia 6008, Australia; and 3Department of Infectious Diseases, Wollongong Hospital, Wollongong, New South Wales 2500, Australia.
Abstract
The impact of pandemic (H1N1) 2009 influenza in HIV-infected individuals is unknown. Determining the prevalence of pandemic influenza in this at-risk group will guide vaccination programs. Following the first pandemic wave, the seroprevalence rate of pandemic influenza in HIV-infected individuals in western Sydney, New South Wales, Australia was 34.2%, similar to the rate observed in the general population. However, true seroprevalence is more accurately determined by seroconversion, defined as a four-fold or greater rise between pre- and post-exposure antibody levels, which was 14.6% in the present study. Seroconversion rates were independent of CD4+ T-lymphocyte count and HIV plasma load. Neither HIV infection, nor severe immunosuppression, was a significant risk factor for pandemic influenza during the first southern hemisphere pandemic wave.
PMID: 21084991 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21084991