tetano
Editor, Senior Moderator
Influenza Other Respi Viruses. 2011 Jul 22. doi: 10.1111/j.1750-2659.2011.00272.x. [Epub ahead of print]
Pandemic H1N1 influenza-associated hospitalizations in children in Madrid, Spain.
Del Rosal T, Baquero-Artigao F, Calvo C, Mellado MJ, Molina JC, Del Mar Santos M, Cilleruelo MJ, Bueno M, de Gracia PS, Terol C, Roa MA, Pi?eiro R, L?pez-Hortelano MG, Garc?a-Garc?a ML, Rodr?guez S, Pen?n M, Zarauza A, Alvarado F, de Blas A, Otheo E, Rodr?guez A, Herreros ML, Tagarro A, Grande L, Ramos JT, Mat? I, Mu?oz C, Zafra MA, Romero-G?mez MP, P?rez-Fern?ndez E, Delgado A, Casas I, Cabezas ME.
Source
Pediatrics Department, Hospital Infanta Elena, Valdemoro, Madrid, Spain. Pediatric Infectious Diseases Unit, Hospital La Paz, Madrid, Spain. Pediatrics Department, Hospital Severo Ochoa, Legan?s, Madrid, Spain. Pediatric Infectious Diseases and Tropical Medicine Unit, Hospital Carlos III, Madrid, Spain. Emergency Department, Hospital Infantil Universitario Ni?o Jes?s, Madrid, Spain. Pediatric Infectious Diseases Unit, Hospital Gregorio Mara??n, Madrid, Spain. Pediatrics Department, Hospital Puerta de Hierro-Majadahonda, Majadahonda, Madrid, Spain. Pediatrics Department, Hospital Fundaci?n Alcorc?n, Alcorc?n, Madrid, Spain. Pediatrics Department, Hospital de M?stoles, M?stoles, Madrid, Spain. Pediatrics Department, Hospital Pr?ncipe de Asturias, Alcal? de Henares, Madrid, Spain. Pediatric Intensive Care Unit, Hospital La Paz, Madrid, Spain. Pediatrics Department, Hospital Ram?n y Cajal, Madrid, Spain. Pediatrics Department, Hospital del Sureste, Arganda del Rey, Madrid, Spain. Pediatrics Department, Hospital Infanta Sof?a, San Sebasti?n de los Reyes, Madrid, Spain. Pediatrics Department, Hospital de Getafe, Getafe, Madrid, Spain. Pediatrics Department, Hospital del Henares, Coslada, Madrid, Spain. Pediatrics Department, Hospital Infanta Leonor, Madrid, Spain. Pediatrics Department, Hospital de Fuenlabrada, Fuelabrada, Madrid, Spain. Microbiology Department, Hospital La Paz, Madrid, Spain. Biostatistics Unit, Hospital La Paz, IdiPaz, Madrid, Spain. Microbiology Department, Hospital Fundaci?n Alcorc?n, Alcorc?n, Madrid, Spain. Influenza and Respiratory Viruses Laboratory, National Centre for Microbiology, Intituto de Sauld Carlos III, Madrid, Spain. Pediatrics Department, Hospital del Tajo, Aranjuez, Madrid, Spain.
Abstract
Please cite this paper as: del Rosal et al. (2011) Pandemic H1N1 influenza-associated hospitalizations in children in Madrid, Spain. Influenza and Other Respiratory Viruses Doi: 10.1111/j.1750-2659.2011.00272.x. Objective To describe the epidemiological and clinical characteristics of children hospitalized with 2009 pandemic influenza (pH1N1) in Madrid, Spain. Patients/Methods We included patients less than 14 years of age admitted to one of 18 hospitals in Madrid, Spain, between May 1 and November 30, 2009 and diagnosed with pH1N1 by polymerase chain reaction. A retrospective chart review was conducted and data were compared by age, presence of high-risk medical conditions, and pediatric intensive care unit (PICU) admission. Results A total of 517 pH1N1 cases were included for final analysis. One hundred and forty-two patients (27?5%) had predisposing underlying illnesses, with immunosuppression (36 children, 7%) and moderate persistent asthma (34, 6?6%) being the most common ones. Patients with underlying medical conditions had longer hospital stays [median 5, interquartile range (IQR) 3-8 days, versus median 4, IQR 3-6, P < 0?001] and required intensive care (20?4% versus 5?9%, P < 0?001) and mechanical ventilation more frequently than previously healthy children. Globally, intensive care was required for 51 patients (10%) and invasive mechanical ventilation for 12 (2%). Pediatric intensive care unit admission was significantly associated with abnormal initial chest X-ray [Odds Ratio (OR) 3?5, 95% confidence interval (CI) 1?5-8?5], underlying neurological condition (OR 3?1, CI 1?2-7?5) and immunosuppression (OR 2?9, 1?2-6?8). Five patients (0?9%) died; two with severe neurological disease, two with leukemia, and one with a malignant solid tumor. Conclusions Children with underlying medical conditions experienced more severe pH1N1 disease. Risk factors for admission to the PICU included underlying neurological conditions, immunosuppression and abnormal initial chest X-ray.
? 2011 Blackwell Publishing Ltd.
PMID:
21781285
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21781285
Pandemic H1N1 influenza-associated hospitalizations in children in Madrid, Spain.
Del Rosal T, Baquero-Artigao F, Calvo C, Mellado MJ, Molina JC, Del Mar Santos M, Cilleruelo MJ, Bueno M, de Gracia PS, Terol C, Roa MA, Pi?eiro R, L?pez-Hortelano MG, Garc?a-Garc?a ML, Rodr?guez S, Pen?n M, Zarauza A, Alvarado F, de Blas A, Otheo E, Rodr?guez A, Herreros ML, Tagarro A, Grande L, Ramos JT, Mat? I, Mu?oz C, Zafra MA, Romero-G?mez MP, P?rez-Fern?ndez E, Delgado A, Casas I, Cabezas ME.
Source
Pediatrics Department, Hospital Infanta Elena, Valdemoro, Madrid, Spain. Pediatric Infectious Diseases Unit, Hospital La Paz, Madrid, Spain. Pediatrics Department, Hospital Severo Ochoa, Legan?s, Madrid, Spain. Pediatric Infectious Diseases and Tropical Medicine Unit, Hospital Carlos III, Madrid, Spain. Emergency Department, Hospital Infantil Universitario Ni?o Jes?s, Madrid, Spain. Pediatric Infectious Diseases Unit, Hospital Gregorio Mara??n, Madrid, Spain. Pediatrics Department, Hospital Puerta de Hierro-Majadahonda, Majadahonda, Madrid, Spain. Pediatrics Department, Hospital Fundaci?n Alcorc?n, Alcorc?n, Madrid, Spain. Pediatrics Department, Hospital de M?stoles, M?stoles, Madrid, Spain. Pediatrics Department, Hospital Pr?ncipe de Asturias, Alcal? de Henares, Madrid, Spain. Pediatric Intensive Care Unit, Hospital La Paz, Madrid, Spain. Pediatrics Department, Hospital Ram?n y Cajal, Madrid, Spain. Pediatrics Department, Hospital del Sureste, Arganda del Rey, Madrid, Spain. Pediatrics Department, Hospital Infanta Sof?a, San Sebasti?n de los Reyes, Madrid, Spain. Pediatrics Department, Hospital de Getafe, Getafe, Madrid, Spain. Pediatrics Department, Hospital del Henares, Coslada, Madrid, Spain. Pediatrics Department, Hospital Infanta Leonor, Madrid, Spain. Pediatrics Department, Hospital de Fuenlabrada, Fuelabrada, Madrid, Spain. Microbiology Department, Hospital La Paz, Madrid, Spain. Biostatistics Unit, Hospital La Paz, IdiPaz, Madrid, Spain. Microbiology Department, Hospital Fundaci?n Alcorc?n, Alcorc?n, Madrid, Spain. Influenza and Respiratory Viruses Laboratory, National Centre for Microbiology, Intituto de Sauld Carlos III, Madrid, Spain. Pediatrics Department, Hospital del Tajo, Aranjuez, Madrid, Spain.
Abstract
Please cite this paper as: del Rosal et al. (2011) Pandemic H1N1 influenza-associated hospitalizations in children in Madrid, Spain. Influenza and Other Respiratory Viruses Doi: 10.1111/j.1750-2659.2011.00272.x. Objective To describe the epidemiological and clinical characteristics of children hospitalized with 2009 pandemic influenza (pH1N1) in Madrid, Spain. Patients/Methods We included patients less than 14 years of age admitted to one of 18 hospitals in Madrid, Spain, between May 1 and November 30, 2009 and diagnosed with pH1N1 by polymerase chain reaction. A retrospective chart review was conducted and data were compared by age, presence of high-risk medical conditions, and pediatric intensive care unit (PICU) admission. Results A total of 517 pH1N1 cases were included for final analysis. One hundred and forty-two patients (27?5%) had predisposing underlying illnesses, with immunosuppression (36 children, 7%) and moderate persistent asthma (34, 6?6%) being the most common ones. Patients with underlying medical conditions had longer hospital stays [median 5, interquartile range (IQR) 3-8 days, versus median 4, IQR 3-6, P < 0?001] and required intensive care (20?4% versus 5?9%, P < 0?001) and mechanical ventilation more frequently than previously healthy children. Globally, intensive care was required for 51 patients (10%) and invasive mechanical ventilation for 12 (2%). Pediatric intensive care unit admission was significantly associated with abnormal initial chest X-ray [Odds Ratio (OR) 3?5, 95% confidence interval (CI) 1?5-8?5], underlying neurological condition (OR 3?1, CI 1?2-7?5) and immunosuppression (OR 2?9, 1?2-6?8). Five patients (0?9%) died; two with severe neurological disease, two with leukemia, and one with a malignant solid tumor. Conclusions Children with underlying medical conditions experienced more severe pH1N1 disease. Risk factors for admission to the PICU included underlying neurological conditions, immunosuppression and abnormal initial chest X-ray.
? 2011 Blackwell Publishing Ltd.
PMID:
21781285
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21781285