tetano
Editor, Senior Moderator
Vaccine. 2015 Feb 26. pii: S0264-410X(15)00224-8. doi: 10.1016/j.vaccine.2015.02.035. [Epub ahead of print]
[h=1]Pandemic influenza A vaccination and incidence of Guillain-Barr? syndrome in Korea.[/h] Kim C[SUP]1[/SUP], Rhie S[SUP]2[/SUP], Suh M[SUP]3[/SUP], Kang DR[SUP]4[/SUP], Choi YJ[SUP]5[/SUP], Bae GR[SUP]6[/SUP], Choi YC[SUP]7[/SUP], Jun BY[SUP]8[/SUP], Lee JS[SUP]9[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Many studies have investigated the association between Guillain-Barr? syndrome (GBS) and vaccinations during the influenza A H1N1 pandemic of 2009 (pH1N1). Based on a nationally representative sample, we estimated the incidence of GBS during the pandemic period in Korea.
[h=4]MATERIALS AND METHODS:[/h] All medical records of GBS cases were reviewed in 28 randomly selected hospitals during 2008-2010, and the number of GBS cases at the national level was extrapolated using emergency care utilization data. The GBS rate per 100,000 person-years was estimated in the reference and pandemic periods.
[h=4]RESULTS:[/h] The incidence of GBS was 0.63 (95% CI: 0.37-0.89) per 100,000 person-years in the reference period and 0.87 (0.49-1.26) in the pandemic period. During the vaccination season, the pandemic period GBS incidence rate was not significantly higher than the reference period incidence rate (Rate ratio: 1.52; 0.99-2.32), but difference was observed among persons aged 20-34 years. Rate of GBS increased after pH1N1 vaccination compared to the reference period (1.46, 1.26-1.68).
[h=4]DISCUSSION:[/h] The incidence of GBS increased slightly but not significantly during the pandemic period, although pH1N1 vaccination increased the GBS rate. Therefore, mass influenza vaccination programs should not be precluded on the basis of GBS.
Copyright ? 2015. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Guillain?Barr? syndrome; Incidence rate; Influenza; Vaccination
PMID: 25728315 [PubMed - as supplied by publisher]
[h=1]Pandemic influenza A vaccination and incidence of Guillain-Barr? syndrome in Korea.[/h] Kim C[SUP]1[/SUP], Rhie S[SUP]2[/SUP], Suh M[SUP]3[/SUP], Kang DR[SUP]4[/SUP], Choi YJ[SUP]5[/SUP], Bae GR[SUP]6[/SUP], Choi YC[SUP]7[/SUP], Jun BY[SUP]8[/SUP], Lee JS[SUP]9[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Many studies have investigated the association between Guillain-Barr? syndrome (GBS) and vaccinations during the influenza A H1N1 pandemic of 2009 (pH1N1). Based on a nationally representative sample, we estimated the incidence of GBS during the pandemic period in Korea.
[h=4]MATERIALS AND METHODS:[/h] All medical records of GBS cases were reviewed in 28 randomly selected hospitals during 2008-2010, and the number of GBS cases at the national level was extrapolated using emergency care utilization data. The GBS rate per 100,000 person-years was estimated in the reference and pandemic periods.
[h=4]RESULTS:[/h] The incidence of GBS was 0.63 (95% CI: 0.37-0.89) per 100,000 person-years in the reference period and 0.87 (0.49-1.26) in the pandemic period. During the vaccination season, the pandemic period GBS incidence rate was not significantly higher than the reference period incidence rate (Rate ratio: 1.52; 0.99-2.32), but difference was observed among persons aged 20-34 years. Rate of GBS increased after pH1N1 vaccination compared to the reference period (1.46, 1.26-1.68).
[h=4]DISCUSSION:[/h] The incidence of GBS increased slightly but not significantly during the pandemic period, although pH1N1 vaccination increased the GBS rate. Therefore, mass influenza vaccination programs should not be precluded on the basis of GBS.
Copyright ? 2015. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Guillain?Barr? syndrome; Incidence rate; Influenza; Vaccination
PMID: 25728315 [PubMed - as supplied by publisher]