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Pandemİc Propagatİon Vİa Lİve Vaccİne (flu Shot)

T

turkali10

Well-known member
The results of the study show that the homologous recombination can
drive mammal influenza A virus evolution, and might result in
potential change of virus virulence and host tropism.
Dynamic gene mutation and the reassortment of genes have been considered as the key factors responsible
for influenza A virus virulence and host tropism change. This study reports several significant evidence
demonstrating that homologous recombination also takes place between influenza A viruses in human and
swine lineages. Moreover, in a mosaic descended from swine H1N1 subtype and human H2N2, we found that
its minor putative parent might be a derivative from the human cold-adapted vaccine lineage, which
suggests that live vaccine is capable of playing a role in genetic change of influenza A virus via recombination
with circulating viruses. These results would be important for knowing the molecular mechanism of
mammal influenza A virus heredity and evolution.

In conclusion, our study provided powerful evidence that intragenic
recombination occurs in mammalian influenza A viruses from
different species, which shows that homologous recombination may
play a role in driving the evolution of mammalian influenza A viruses
and has the potential to change their virulence and host tropism.
Finally, our results suggest that live vaccine is capable of speeding up
viral evolution via recombination with circulating viruses.

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Re: Pandemİc Propagatİon Vİa Lİve Vaccİne (flu Shot)

#1: ...


So, live vacines are better to be bracketed.
 
Re: Pandemİc Propagatİon Vİa Lİve Vaccİne (flu Shot)

yes they know that long time,
so why some producers stil create live vaccines ...
 
Re: Pandemİc Propagatİon Vİa Lİve Vaccİne (flu Shot)

this recombination is rare in humans.

hopefully all strains of life vaccine are going to be reported
and published
I'd like to see the list !
 
Re: Pandemİc Propagatİon Vİa Lİve Vaccİne (flu Shot)

#7: "hopefully all strains of life vaccine are going to be reported
and published"


I doubt such thing can be accomplished when they did not tested masses of humans pand. light infected and not hospitalized.

And more important, even if tracked, such lab paperwork will not stop the changeings.

That's why we are moving flybye more and more new microbes.

Obviously new regulations are needed ...
 
Re: Pandemİc Propagatİon Vİa Lİve Vaccİne (flu Shot)

"That's why we are moving flybye more and more new microbes.

Obviously new regulations are needed ... "



In fact, the descendents of the influenza A (H1N1) virus that
caused the catastrophic and historic pandemic of 1918 have per-
sisted for more than 90 years and have continued to produce reas-
sorted viruses, causing new pandemics, endemics, epidemics. This
would virtually suggest that we are living in a pandemic era that
began around 1918. Ever since 1918, this tenacious virus has
drawn on a bag of evolutionary tricks to survive in one form or an-
other through reassortment events. The closer evolutionary dis-
tance between the 1918 and 2009 pandemic strain and the 1998
triple reassorted swine viruses observed in the present study sug-
gest the need to trace the evolutionary origins of the 1918 strain, as
different analyses suggest different views


http://download.thelancet.com/flatcontentassets/H1N1-flu/virology/virology-48.pdf
 
Re: Pandemİc Propagatİon Vİa Lİve Vaccİne (flu Shot)

Thank you turkali10 - very interesting - and welcome.
 
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