tetano
Editor, Senior Moderator
Panminerva Med
. 2020 Oct 19.
doi: 10.23736/S0031-0808.20.04157-9. Online ahead of print.
SARS-CoV-2-related lung pathology: macroscopic and histologic features and their clinical implications
Francesca Sanguedolce[SUP] 1 [/SUP], Magda Zanelli[SUP] 2 [/SUP], Stefano Ascani[SUP] 3 [/SUP], Maurizio Zizzo[SUP] 4 5 [/SUP], Simona Tortorella[SUP] 6 [/SUP], Alessandra Soriano[SUP] 7 [/SUP], Alberto Cavazza[SUP] 2 [/SUP], Francesco Sollitto[SUP] 8 [/SUP], Domenico Loizzi[SUP] 8 [/SUP]
Affiliations
Abstract
The ongoing global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been posing challenges to proper patients' management. Lungs are the first, and often the most affected organ by SARS-CoV-2; viral infection involves and damages both epithelial and vascular compartments, sometimes leading to severe and even fatal acute respiratory distress syndrome. Histopathological findings, mainly from postmortem examination of COVID-19 deceased patients, have been increasingly published in the last few months, helping to elucidate the sequence of events resulting in organ injury, and the complex multifactorial pathogenesis of this novel disease. A multidisciplinary approach to autopsy, including light microscopy examination along with the detection of viral proteins and/or RNA in tissue samples through ancillary techniques, provided crucial information on the mechanisms underlying the often-heterogeneous clinical picture of COVID-19.
. 2020 Oct 19.
doi: 10.23736/S0031-0808.20.04157-9. Online ahead of print.
SARS-CoV-2-related lung pathology: macroscopic and histologic features and their clinical implications
Francesca Sanguedolce[SUP] 1 [/SUP], Magda Zanelli[SUP] 2 [/SUP], Stefano Ascani[SUP] 3 [/SUP], Maurizio Zizzo[SUP] 4 5 [/SUP], Simona Tortorella[SUP] 6 [/SUP], Alessandra Soriano[SUP] 7 [/SUP], Alberto Cavazza[SUP] 2 [/SUP], Francesco Sollitto[SUP] 8 [/SUP], Domenico Loizzi[SUP] 8 [/SUP]
Affiliations
- PMID: 33073555
- DOI: 10.23736/S0031-0808.20.04157-9
Abstract
The ongoing global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been posing challenges to proper patients' management. Lungs are the first, and often the most affected organ by SARS-CoV-2; viral infection involves and damages both epithelial and vascular compartments, sometimes leading to severe and even fatal acute respiratory distress syndrome. Histopathological findings, mainly from postmortem examination of COVID-19 deceased patients, have been increasingly published in the last few months, helping to elucidate the sequence of events resulting in organ injury, and the complex multifactorial pathogenesis of this novel disease. A multidisciplinary approach to autopsy, including light microscopy examination along with the detection of viral proteins and/or RNA in tissue samples through ancillary techniques, provided crucial information on the mechanisms underlying the often-heterogeneous clinical picture of COVID-19.