tetano
Editor, Senior Moderator
Pathobiology
. 2020 Oct 13;1-13.
doi: 10.1159/000512007. Online ahead of print.
The Impact of COVID-19 Disease on Platelets and Coagulation
Geoffrey D Wool[SUP] 1 [/SUP], Jonathan L Miller[SUP] 2 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) causes a spectrum of disease; some patients develop a severe proinflammatory state which can be associated with a unique coagulopathy and procoagulant endothelial phenotype. Initially, COVID-19 infection produces a prominent elevation of fibrinogen and D-dimer/fibrin(ogen) degradation products. This is associated with systemic hypercoagulability and frequent venous thromboembolic events. The degree of D-dimer elevation positively correlates with mortality in COVID-19 patients. COVID-19 also leads to arterial thrombotic events (including strokes and ischemic limbs) as well as microvascular thrombotic disorders (as frequently documented at autopsy in the pulmonary vascular beds). COVID-19 patients often have mild thrombocytopenia and appear to have increased platelet consumption, together with a corresponding increase in platelet production. Disseminated intravascular coagulopathy (DIC) and severe bleeding events are uncommon in COVID-19 patients. Here, we review the current state of knowledge of COVID-19 and hemostasis.
Keywords: COVID-19; Coagulopathy; D-dimer; Thrombocytopenia; Thrombosis.
. 2020 Oct 13;1-13.
doi: 10.1159/000512007. Online ahead of print.
The Impact of COVID-19 Disease on Platelets and Coagulation
Geoffrey D Wool[SUP] 1 [/SUP], Jonathan L Miller[SUP] 2 [/SUP]
Affiliations
- PMID: 33049751
- DOI: 10.1159/000512007
Abstract
Coronavirus disease 2019 (COVID-19) causes a spectrum of disease; some patients develop a severe proinflammatory state which can be associated with a unique coagulopathy and procoagulant endothelial phenotype. Initially, COVID-19 infection produces a prominent elevation of fibrinogen and D-dimer/fibrin(ogen) degradation products. This is associated with systemic hypercoagulability and frequent venous thromboembolic events. The degree of D-dimer elevation positively correlates with mortality in COVID-19 patients. COVID-19 also leads to arterial thrombotic events (including strokes and ischemic limbs) as well as microvascular thrombotic disorders (as frequently documented at autopsy in the pulmonary vascular beds). COVID-19 patients often have mild thrombocytopenia and appear to have increased platelet consumption, together with a corresponding increase in platelet production. Disseminated intravascular coagulopathy (DIC) and severe bleeding events are uncommon in COVID-19 patients. Here, we review the current state of knowledge of COVID-19 and hemostasis.
Keywords: COVID-19; Coagulopathy; D-dimer; Thrombocytopenia; Thrombosis.