tetano
Editor, Senior Moderator
Vet Pathol. 2016 Sep 30. pii: 0300985816671377. [Epub ahead of print]
[h=1]Pathologic Findings and Viral Antigen Distribution During Natural Infection of Ring-Necked Pheasants With H5N2 Highly Pathogenic Avian Influenza Virus A.[/h] Ajithdoss DK[SUP]1[/SUP], Torchetti MK[SUP]2[/SUP], Badcoe L[SUP]3[/SUP], Bradway DS[SUP]4[/SUP], Baszler TV[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Highly pathogenic avian influenza (HPAI) is a major viral disease of poultry characterized by acute onset, systemic infection, and rapid death. In January 2015, H5N2 HPAI was identified by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) and gene sequencing as the cause of rapid death in 40 of 390 ring-necked pheasants (approximately 10% mortality), raised in a game bird farm in Washington State. We report clinicopathologic findings and viral antigen distribution in pheasants that died during the outbreak. Affected birds were depressed with reluctance to move, ruffled feathers, and drooping heads. Congestion of the cerebellar meningeal blood vessels was the only consistent gross pathologic finding. Meningoencephalitis with vasculitis and necrosis in the spleen and heart were the major microscopic lesions in the birds. Viral antigen was consistently detected in the brain, heart, and ovary with variable presence in other organs.
? The Author(s) 2016.
[h=4]KEYWORDS:[/h] Phasianus colchicus ; H5N2; avian influenza virus; common pheasant; immunohistochemistry; pathology
PMID: 27694426 DOI: 10.1177/0300985816671377
[PubMed - as supplied by publisher]
[h=1]Pathologic Findings and Viral Antigen Distribution During Natural Infection of Ring-Necked Pheasants With H5N2 Highly Pathogenic Avian Influenza Virus A.[/h] Ajithdoss DK[SUP]1[/SUP], Torchetti MK[SUP]2[/SUP], Badcoe L[SUP]3[/SUP], Bradway DS[SUP]4[/SUP], Baszler TV[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Highly pathogenic avian influenza (HPAI) is a major viral disease of poultry characterized by acute onset, systemic infection, and rapid death. In January 2015, H5N2 HPAI was identified by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) and gene sequencing as the cause of rapid death in 40 of 390 ring-necked pheasants (approximately 10% mortality), raised in a game bird farm in Washington State. We report clinicopathologic findings and viral antigen distribution in pheasants that died during the outbreak. Affected birds were depressed with reluctance to move, ruffled feathers, and drooping heads. Congestion of the cerebellar meningeal blood vessels was the only consistent gross pathologic finding. Meningoencephalitis with vasculitis and necrosis in the spleen and heart were the major microscopic lesions in the birds. Viral antigen was consistently detected in the brain, heart, and ovary with variable presence in other organs.
? The Author(s) 2016.
[h=4]KEYWORDS:[/h] Phasianus colchicus ; H5N2; avian influenza virus; common pheasant; immunohistochemistry; pathology
PMID: 27694426 DOI: 10.1177/0300985816671377
[PubMed - as supplied by publisher]