tetano
Editor, Senior Moderator
Pediatr Emerg Care
. 2023 Apr 21.
doi: 10.1097/PEC.0000000000002935. Online ahead of print.
The Association Between COVID-19 and Febrile Seizure: A Retrospective Case-Control Study
Sean M Hanlon[SUP] 1 [/SUP], Don Sim[SUP] 2 [/SUP], Jack G Schneider[SUP] 3 [/SUP], Ziyi Yang[SUP] 4 [/SUP], Sean M Thompson[SUP] 5 [/SUP]
Affiliations
Abstract
Background/objective: Throughout the pandemic, febrile seizures have resulted from infection secondary to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The objective of this study is to determine if there is an increased association between COVID-19 and febrile seizures as compared with other causes of febrile seizures.
Methods: This was a retrospective case control study. Data were collected from the National Institute of Health (NIH) supported National COVID Cohort Collaborative (N3C). Patients from 6 to 60 months who were tested for COVID-19 were included; cases were defined as COVID-19-positive patients whereas controls were defined as COVID-19-negative patients. Febrile seizures diagnosed within 48 hours of the COVID-19 test were considered to be associated with the test result. Patients were subjected to a stratified gender and date matching design followed by a logistic regression controlling for age and race.
Results: During the study period, 27,692 patients were included. Of those, 6923 patients were COVID-19-positive, among which 189 had febrile seizures (2.7%). After logistic regression, the likelihood of having febrile seizures concurrently with COVID-19 as compared with other causes was 0.96 (P = 0.949; confidence interval, 0.81, 1.14).
Conclusions: There were 2.7% of the patients with COVID-19 that were diagnosed with a febrile seizure. However, when subjected to a matched case control design with logistic regression controlling for confounding variables, there does not appear to be an increased risk of febrile seizures secondary to COVID-19 as compared with other causes.
. 2023 Apr 21.
doi: 10.1097/PEC.0000000000002935. Online ahead of print.
The Association Between COVID-19 and Febrile Seizure: A Retrospective Case-Control Study
Sean M Hanlon[SUP] 1 [/SUP], Don Sim[SUP] 2 [/SUP], Jack G Schneider[SUP] 3 [/SUP], Ziyi Yang[SUP] 4 [/SUP], Sean M Thompson[SUP] 5 [/SUP]
Affiliations
- PMID: 37079552
- DOI: 10.1097/PEC.0000000000002935
Abstract
Background/objective: Throughout the pandemic, febrile seizures have resulted from infection secondary to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The objective of this study is to determine if there is an increased association between COVID-19 and febrile seizures as compared with other causes of febrile seizures.
Methods: This was a retrospective case control study. Data were collected from the National Institute of Health (NIH) supported National COVID Cohort Collaborative (N3C). Patients from 6 to 60 months who were tested for COVID-19 were included; cases were defined as COVID-19-positive patients whereas controls were defined as COVID-19-negative patients. Febrile seizures diagnosed within 48 hours of the COVID-19 test were considered to be associated with the test result. Patients were subjected to a stratified gender and date matching design followed by a logistic regression controlling for age and race.
Results: During the study period, 27,692 patients were included. Of those, 6923 patients were COVID-19-positive, among which 189 had febrile seizures (2.7%). After logistic regression, the likelihood of having febrile seizures concurrently with COVID-19 as compared with other causes was 0.96 (P = 0.949; confidence interval, 0.81, 1.14).
Conclusions: There were 2.7% of the patients with COVID-19 that were diagnosed with a febrile seizure. However, when subjected to a matched case control design with logistic regression controlling for confounding variables, there does not appear to be an increased risk of febrile seizures secondary to COVID-19 as compared with other causes.