tetano
Editor, Senior Moderator
Pediatr Infect Dis J
. 2021 Sep 17.
doi: 10.1097/INF.0000000000003325. Online ahead of print.
Antibodies to Seasonal Coronaviruses Rarely Cross-React with SARS-CoV-2: Findings from an African Birth Cohort
Heather J Zar[SUP] 1 [/SUP], Mark P Nicol, Rae MacGinty, Lesley Workman, Wonita Petersen, Marina Johnson, David Goldblatt
Affiliations
Abstract
Antibodies to seasonal human-coronaviruses (sHCoV) may cross-protect against SARS-CoV-2. We investigated antibody responses in biobanked serum obtained before the pandemic from infants with polymerase chain reaction-confirmed sHCoV. Among 141 samples with antibodies to sHCoV, 4 (2.8%) were positive for SARS-CoV-2-S1 and 8 (5.7%) for SARS-CoV-2-S2. Antibodies to sHCoV rarely cross-react with SARS-CoV-2 antigens and are unlikely to account for mild pediatric illness.
. 2021 Sep 17.
doi: 10.1097/INF.0000000000003325. Online ahead of print.
Antibodies to Seasonal Coronaviruses Rarely Cross-React with SARS-CoV-2: Findings from an African Birth Cohort
Heather J Zar[SUP] 1 [/SUP], Mark P Nicol, Rae MacGinty, Lesley Workman, Wonita Petersen, Marina Johnson, David Goldblatt
Affiliations
- PMID: 34533491
- DOI: 10.1097/INF.0000000000003325
Abstract
Antibodies to seasonal human-coronaviruses (sHCoV) may cross-protect against SARS-CoV-2. We investigated antibody responses in biobanked serum obtained before the pandemic from infants with polymerase chain reaction-confirmed sHCoV. Among 141 samples with antibodies to sHCoV, 4 (2.8%) were positive for SARS-CoV-2-S1 and 8 (5.7%) for SARS-CoV-2-S2. Antibodies to sHCoV rarely cross-react with SARS-CoV-2 antigens and are unlikely to account for mild pediatric illness.