tetano
Editor, Senior Moderator
Pediatr Infect Dis J. 2016 Nov 28. [Epub ahead of print]
[h=1]Influenza Vaccine Effectiveness in Preventing Influenza Illness Among Children During School-Based Outbreaks in the 2014-2015 Season in Beijing, China.[/h] Zhang L[SUP]1[/SUP], Yang P, Thompson MG, Pan Y, Ma C, Wu S, Sun Y, Zhang M, Duan W, Wang Q.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Little is known about VE against non-medically attended A(H3N2) influenza illness during 2014-2015 when the vaccine component appeared to be a poor match with circulating strains.
[h=4]METHODS:[/h] Forty-three eligible school influenza outbreaks in Beijing, China from November 1 to December 31, 2014 were included in this study. The VE of 2014-2015 trivalent inactivated influenza vaccine (IIV3) was assessed in preventing laboratory-confirmed influenza among school-age children through a case-control design, using asymptomatic controls. Influenza vaccination was documented from a vaccination registry. VE was estimated adjusting for age group, sex, rural vs. urban area, body mass index, chronic conditions, onset week and schools through a mixed effects logistic regression model.
[h=4]RESULTS:[/h] The average coverage rate of 2014-2015 IIV3 among students across the 43 schools was 47.6%. The fully adjusted VE of 2014-2015 IIV3 against laboratory-confirmed influenza was 38% (95% CI: 12% to 57%). Receipt of previous season's (2013-2014) IIV3 significantly modified VE of the 2014-2015 IIV3; children who received both 2013-2014 and 2014-2015 vaccinations had VE of 29% (95% CI: -8% to 53%) while VE for children who received 2014-2015 IIV3 only was 54% (95% CI: 8% to 77%).
[h=4]CONCLUSIONS:[/h] VE for 2014-2015 IIV3 against A (H3N2) illness identified in schools was modest. Children who did not receive the prior season's vaccine with a homologous A (H3N2) component may have enjoyed greater protection than repeated vaccinees.
PMID: 27902651 DOI: 10.1097/INF.0000000000001434
[PubMed - as supplied by publisher]
[h=1]Influenza Vaccine Effectiveness in Preventing Influenza Illness Among Children During School-Based Outbreaks in the 2014-2015 Season in Beijing, China.[/h] Zhang L[SUP]1[/SUP], Yang P, Thompson MG, Pan Y, Ma C, Wu S, Sun Y, Zhang M, Duan W, Wang Q.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Little is known about VE against non-medically attended A(H3N2) influenza illness during 2014-2015 when the vaccine component appeared to be a poor match with circulating strains.
[h=4]METHODS:[/h] Forty-three eligible school influenza outbreaks in Beijing, China from November 1 to December 31, 2014 were included in this study. The VE of 2014-2015 trivalent inactivated influenza vaccine (IIV3) was assessed in preventing laboratory-confirmed influenza among school-age children through a case-control design, using asymptomatic controls. Influenza vaccination was documented from a vaccination registry. VE was estimated adjusting for age group, sex, rural vs. urban area, body mass index, chronic conditions, onset week and schools through a mixed effects logistic regression model.
[h=4]RESULTS:[/h] The average coverage rate of 2014-2015 IIV3 among students across the 43 schools was 47.6%. The fully adjusted VE of 2014-2015 IIV3 against laboratory-confirmed influenza was 38% (95% CI: 12% to 57%). Receipt of previous season's (2013-2014) IIV3 significantly modified VE of the 2014-2015 IIV3; children who received both 2013-2014 and 2014-2015 vaccinations had VE of 29% (95% CI: -8% to 53%) while VE for children who received 2014-2015 IIV3 only was 54% (95% CI: 8% to 77%).
[h=4]CONCLUSIONS:[/h] VE for 2014-2015 IIV3 against A (H3N2) illness identified in schools was modest. Children who did not receive the prior season's vaccine with a homologous A (H3N2) component may have enjoyed greater protection than repeated vaccinees.
PMID: 27902651 DOI: 10.1097/INF.0000000000001434
[PubMed - as supplied by publisher]