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Pediatr Infect Dis J . Specific IgA, But Not IgG, in Human Milk From COVID-19-infected Mothers Neutralizes SARS-CoV-2

tetano

tetano

Editor, Senior Moderator
Pediatr Infect Dis J


. 2024 Feb 29.
doi: 10.1097/INF.0000000000004291. Online ahead of print. Specific IgA, But Not IgG, in Human Milk From COVID-19-infected Mothers Neutralizes SARS-CoV-2

Patricia Macchiaverni[SUP] 1 2 [/SUP], Megan Lloyd[SUP] 1 2 3 [/SUP], Laura Masters[SUP] 3 [/SUP], Nivedithaa Divakara[SUP] 1 2 [/SUP], Kritu Panta[SUP] 3 [/SUP], Allison Imrie[SUP] 3 [/SUP], Laura Sánchez-García[SUP] 4 [/SUP], Adelina Pellicer[SUP] 4 [/SUP], Juan M Rodriguez[SUP] 5 [/SUP], Valerie Verhasselt[SUP] 1 2 [/SUP]



Affiliations
Abstract

This study highlights the importance of human milk in providing anti-severe acute respiratory syndrome coronavirus 2 immunity to newborns. The highest protective activity of human milk against COVID-19 was found in colostrum from infected mothers. Neutralizing activity was associated with high levels of specific IgA. Depletion of IgA, but not IgG, from milk samples completely abolished the ability of human milk to neutralize severe acute respiratory syndrome coronavirus 2.


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