tetano
Editor, Senior Moderator
Pediatr Infect Dis J. 2020 May 5. doi: 10.1097/INF.0000000000002729. [Epub ahead of print]
Symptomatic Infection is Associated with Prolonged Duration of Viral Shedding in Mild Coronavirus Disease 2019: A Retrospective Study of 110 Children in Wuhan.
Lu Y[SUP]1[/SUP], Li Y[SUP]2[/SUP], Deng W[SUP]1[/SUP], Liu M[SUP]3[/SUP], He Y[SUP]1[/SUP], Huang L[SUP]1[/SUP], Lv M[SUP]1[/SUP], Li J[SUP]2[/SUP], Du H[SUP]1[/SUP].
Author information
Abstract
BACKGROUND:
Information regarding viral shedding in children with coronavirus disease 2019 (COVID-19) was limited. This study aims to investigate the clinical and laboratory characteristics associated with viral shedding in children with mild COVID-19.
METHODS:
The clinical and laboratory information of 110 children with COVID-19 at Wuhan Children's Hospital, Wuhan, China, from January 30 to March 10, 2020, were analyzed retrospectively.
RESULTS:
The median age was 6 years old. The median period of viral shedding of COVID-19 was 15 days (interquartile range [IQR], 11-20 days) as measured from illness onset to discharge. This period was shorter in asymptomatic patients (26.4%) compared with symptomatic patients (73.6%) (11 days vs. 17 days). Multivariable regression analysis showed increased odds of symptomatic infection was associated with age <6 years (odds ratio [OR] 8.94, 95% confidence interval [CI]: 2.55-31.35; P = 0.001), hypersensitive C-reactive protein >3.0 mg/L (OR 4.89; 95% CI: 1.10-21.75; P = 0.037) and presenting pneumonia in chest radiologic findings (OR 8.45; 95% CI: 2.69-26.61; P < 0.001). Kaplan-Meier analysis displayed symptomatic infection (P < 0.001), fever (P = 0.006), pneumonia (P = 0.003) and lymphocyte counts <2.0 ? 10/L (P = 0.008) in children with COVID-19 were associated with prolonged duration of viral shedding in children with COVID-19.
CONCLUSION:
Prolonged duration of viral shedding in children with COVID-19 was associated with symptomatic infection, fever, pneumonia and lymphocyte count =2.0 ? 10/L. Monitoring of symptoms could help to know the viral shedding in children with COVID-19.
PMID:32379191DOI:10.1097/INF.0000000000002729
Symptomatic Infection is Associated with Prolonged Duration of Viral Shedding in Mild Coronavirus Disease 2019: A Retrospective Study of 110 Children in Wuhan.
Lu Y[SUP]1[/SUP], Li Y[SUP]2[/SUP], Deng W[SUP]1[/SUP], Liu M[SUP]3[/SUP], He Y[SUP]1[/SUP], Huang L[SUP]1[/SUP], Lv M[SUP]1[/SUP], Li J[SUP]2[/SUP], Du H[SUP]1[/SUP].
Author information
Abstract
BACKGROUND:
Information regarding viral shedding in children with coronavirus disease 2019 (COVID-19) was limited. This study aims to investigate the clinical and laboratory characteristics associated with viral shedding in children with mild COVID-19.
METHODS:
The clinical and laboratory information of 110 children with COVID-19 at Wuhan Children's Hospital, Wuhan, China, from January 30 to March 10, 2020, were analyzed retrospectively.
RESULTS:
The median age was 6 years old. The median period of viral shedding of COVID-19 was 15 days (interquartile range [IQR], 11-20 days) as measured from illness onset to discharge. This period was shorter in asymptomatic patients (26.4%) compared with symptomatic patients (73.6%) (11 days vs. 17 days). Multivariable regression analysis showed increased odds of symptomatic infection was associated with age <6 years (odds ratio [OR] 8.94, 95% confidence interval [CI]: 2.55-31.35; P = 0.001), hypersensitive C-reactive protein >3.0 mg/L (OR 4.89; 95% CI: 1.10-21.75; P = 0.037) and presenting pneumonia in chest radiologic findings (OR 8.45; 95% CI: 2.69-26.61; P < 0.001). Kaplan-Meier analysis displayed symptomatic infection (P < 0.001), fever (P = 0.006), pneumonia (P = 0.003) and lymphocyte counts <2.0 ? 10/L (P = 0.008) in children with COVID-19 were associated with prolonged duration of viral shedding in children with COVID-19.
CONCLUSION:
Prolonged duration of viral shedding in children with COVID-19 was associated with symptomatic infection, fever, pneumonia and lymphocyte count =2.0 ? 10/L. Monitoring of symptoms could help to know the viral shedding in children with COVID-19.
PMID:32379191DOI:10.1097/INF.0000000000002729