tetano
Editor, Senior Moderator
Pediatr Pulmonol
. 2023 Aug 10.
doi: 10.1002/ppul.26614. Online ahead of print. Clinical and epidemiological features and severity markers in children admitted with multisystem inflammatory syndrome in children (MISC) in a tertiary care center in the United Arab Emirates
Habiba H AboAlEla[SUP] 1 [/SUP], Abdulrahman Y Ali[SUP] 1 [/SUP], Ghadah A Al-Sharif[SUP] 1 [/SUP], Walid Abuhammour[SUP] 2 [/SUP], Ahmad Abou Tayoun[SUP] 2 [/SUP], Mohammad Almoosa[SUP] 1 [/SUP], Diego Arango Uribe[SUP] 2 [/SUP], Ali Al-Fraihat[SUP] 2 [/SUP], Samuel B Ho[SUP] 1 3 [/SUP], Amar H Khamis[SUP] 1 4 [/SUP], Rizwana Popatia[SUP] 1 5 [/SUP], Lemis Yavuz[SUP] 2 [/SUP]
Affiliations
Background: Multisystem inflammatory syndrome in children (MISC) is a phenomenon that appeared in children infected with or exposed to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The typical onset of MISC is 4-6 weeks following SARS-CoV-2 infection and is formulated to be due to an immune response.
Methods: Our study retrospectively analyzed data from a tertiary center in United Arab Emirates of MISC patients who were admitted to either general pediatric wards or pediatric intensive care (PICU) or who came exclusively for follow-up (post-PICU admission) from May 2020 to August 2021.
Results: The total sample size was 50 patients, and the study included a comparison of MISC-PICU admissions with MISC-non-PICU admissions. The MISC-PICU sample size was 18 patients, 50% females, with mean age of 8.3 years all were previously healthy. MISC-PICU patients had deranged blood counts with a lower hemoglobin count, a more pronounced lymphopenia and thrombocytopenia along with hypoalbuminemia. MISC-PICU patients presented with relatively higher inflammatory markers: C-reactive protein, procalcitonin, ferritin, and d-dimer. Immunological studies were significantly higher for interleukin-6 levels in PICU patients. On echocardiography, higher myocardial dysfunction was more notable in MISC-PICU patients. Likewise, MISC-PICU patients were provided with more extensive therapy. As part of our study course, we reevaluated our MISC-PICU patients twice, once at 48 h post-PICU admission and again 4-6 weeks after discharge from the hospital. No deaths have been recorded in the cohort.
Conclusion: This study evaluated risk factors of MISC and potential severity features. Follow-up of patients on discharge showed improvement across all domains.
Keywords: COVID-19; MISC; PICU; SARS-COV2; children; clinical features; pediatrics.
. 2023 Aug 10.
doi: 10.1002/ppul.26614. Online ahead of print. Clinical and epidemiological features and severity markers in children admitted with multisystem inflammatory syndrome in children (MISC) in a tertiary care center in the United Arab Emirates
Habiba H AboAlEla[SUP] 1 [/SUP], Abdulrahman Y Ali[SUP] 1 [/SUP], Ghadah A Al-Sharif[SUP] 1 [/SUP], Walid Abuhammour[SUP] 2 [/SUP], Ahmad Abou Tayoun[SUP] 2 [/SUP], Mohammad Almoosa[SUP] 1 [/SUP], Diego Arango Uribe[SUP] 2 [/SUP], Ali Al-Fraihat[SUP] 2 [/SUP], Samuel B Ho[SUP] 1 3 [/SUP], Amar H Khamis[SUP] 1 4 [/SUP], Rizwana Popatia[SUP] 1 5 [/SUP], Lemis Yavuz[SUP] 2 [/SUP]
Affiliations
- PMID: 37565706
- DOI: 10.1002/ppul.26614
Background: Multisystem inflammatory syndrome in children (MISC) is a phenomenon that appeared in children infected with or exposed to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The typical onset of MISC is 4-6 weeks following SARS-CoV-2 infection and is formulated to be due to an immune response.
Methods: Our study retrospectively analyzed data from a tertiary center in United Arab Emirates of MISC patients who were admitted to either general pediatric wards or pediatric intensive care (PICU) or who came exclusively for follow-up (post-PICU admission) from May 2020 to August 2021.
Results: The total sample size was 50 patients, and the study included a comparison of MISC-PICU admissions with MISC-non-PICU admissions. The MISC-PICU sample size was 18 patients, 50% females, with mean age of 8.3 years all were previously healthy. MISC-PICU patients had deranged blood counts with a lower hemoglobin count, a more pronounced lymphopenia and thrombocytopenia along with hypoalbuminemia. MISC-PICU patients presented with relatively higher inflammatory markers: C-reactive protein, procalcitonin, ferritin, and d-dimer. Immunological studies were significantly higher for interleukin-6 levels in PICU patients. On echocardiography, higher myocardial dysfunction was more notable in MISC-PICU patients. Likewise, MISC-PICU patients were provided with more extensive therapy. As part of our study course, we reevaluated our MISC-PICU patients twice, once at 48 h post-PICU admission and again 4-6 weeks after discharge from the hospital. No deaths have been recorded in the cohort.
Conclusion: This study evaluated risk factors of MISC and potential severity features. Follow-up of patients on discharge showed improvement across all domains.
Keywords: COVID-19; MISC; PICU; SARS-COV2; children; clinical features; pediatrics.