tetano
Editor, Senior Moderator
Pediatr Pulmonol
. 2025 Apr;60(4):e71094.
doi: 10.1002/ppul.71094. COVID-19 in Children With Severe Lung Disease-A Tertiary Center Cohort Study in Denmark
Esben Lægsgaard[SUP] 1 [/SUP], Signe Bødker Thim[SUP] 1 [/SUP], Mette Holm[SUP] 2 [/SUP], Sune Rubak[SUP] 1 [/SUP]
Affiliations
Background: Severe lung disease such as chronic pulmonary disease (CPD), severe asthma and cystic fibrosis (CF) in children is associated with increased risk of severe COVID-19. Information regarding SARS-CoV-2 infection, disease severity and outcome of COVID-19 is limited in this pediatric population.
Objectives: We captured the number of SARS-CoV-2 infected children and evaluated COVID-19 disease severity in non-immunized children with CPD, asthma, and CF in a cohort at a Danish tertiary center.
Methods: The number of children with PCR-verified SARS-CoV-2 infection in the cohort and in the age-related background population was identified through the Danish Microbiology Database. Clinical data were retrieved from the electronic medical health records and from the Danish Health Authority.
Results: In a cohort of 664 children with severe lung disease 594 were either PCR-tested or had an antibody test for SARS-CoV-2 infection due to symptoms or exposure and 18 (3%) had verified SARS-CoV-2 infection. The total number of verified SARS-CoV-2 infection was at that time 34.575(4.342%) thus, not significantly different from the reference population (p = 0.152). The symptoms ranged from asymptomatic to mild symptoms, and none of the children with severe lung disease required hospitalization due to COVID-19. None of the children were treated with antiviral treatment during the acute infection.
Conclusion: Of the 664 children in the Danish cohort with severe lung disease, none were hospitalized with COVID-19. Our findings imply that this particular group of patients do not experience increased risk of severe COVID-19.
Keywords: COVID‐19; SARS‐CoV‐2; children; hospitalization; lung disease; pediatrics.
. 2025 Apr;60(4):e71094.
doi: 10.1002/ppul.71094. COVID-19 in Children With Severe Lung Disease-A Tertiary Center Cohort Study in Denmark
Esben Lægsgaard[SUP] 1 [/SUP], Signe Bødker Thim[SUP] 1 [/SUP], Mette Holm[SUP] 2 [/SUP], Sune Rubak[SUP] 1 [/SUP]
Affiliations
- PMID: 40243356
- DOI: 10.1002/ppul.71094
Background: Severe lung disease such as chronic pulmonary disease (CPD), severe asthma and cystic fibrosis (CF) in children is associated with increased risk of severe COVID-19. Information regarding SARS-CoV-2 infection, disease severity and outcome of COVID-19 is limited in this pediatric population.
Objectives: We captured the number of SARS-CoV-2 infected children and evaluated COVID-19 disease severity in non-immunized children with CPD, asthma, and CF in a cohort at a Danish tertiary center.
Methods: The number of children with PCR-verified SARS-CoV-2 infection in the cohort and in the age-related background population was identified through the Danish Microbiology Database. Clinical data were retrieved from the electronic medical health records and from the Danish Health Authority.
Results: In a cohort of 664 children with severe lung disease 594 were either PCR-tested or had an antibody test for SARS-CoV-2 infection due to symptoms or exposure and 18 (3%) had verified SARS-CoV-2 infection. The total number of verified SARS-CoV-2 infection was at that time 34.575(4.342%) thus, not significantly different from the reference population (p = 0.152). The symptoms ranged from asymptomatic to mild symptoms, and none of the children with severe lung disease required hospitalization due to COVID-19. None of the children were treated with antiviral treatment during the acute infection.
Conclusion: Of the 664 children in the Danish cohort with severe lung disease, none were hospitalized with COVID-19. Our findings imply that this particular group of patients do not experience increased risk of severe COVID-19.
Keywords: COVID‐19; SARS‐CoV‐2; children; hospitalization; lung disease; pediatrics.