Emily
Editor, Senior Moderator
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129962/
Kilic MA, Yoruk Yildirim ZN, Oner A, et al. Pediatric LGI1 and CASPR2 autoimmunity associated with COVID 19: Morvan syndrome [published online ahead of print, 2021 May 18]. J Neurol. 2021;1-3. doi:10.1007/s00415-021-10614-6
Dear Sirs,
Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) most commonly affects the respiratory system, autoimmune neurological presentations have also been reported [1, 2]. More recently Burr et al. have reported a pediatric patient with SARS-CoV-2-associated anti-NMDAR encephalitis [1]. Although anti-NMDAR encephalitis is one of the most common types of autoimmune encephalitis (AIE) leucine-rich glioma-inactivated protein 1 (LGI1) and contactin-associated protein 2 (CASPR2)-associated autoimmunity is rare in children. LGI1 and CASPR2 are the main antigens within the voltage-gated potassium channel-complex (VGKC). LGI1 and CASPR2 autoimmunity is associated with limbic encephalitis, isolated epilepsy, Morvan syndrome and neuromyotonia [3]. Morvan syndrome is characterized by neuromyotonia, dysautonomia, insomnia and neuropsychiatric symptoms [3, 4]. Here we present the pediatric patient with SARS-CoV-2-associated Morvan syndrome initially present with Guillain–Barre syndrome.
A previously healthy 3-year-old girl has admitted to an outside hospital for a history of sleep dysregulation and irritability followed by lower extremities weakness with difficulty in walking for 2 months ago. Her first examination had revealed tachycardia, arterial hypertension, ataxia and abolished deep tendon reflexes of the lower extremities. She had family history of coronavirus disease 2019 (COVID-19) 4 weeks before her symptoms developed...
Kilic MA, Yoruk Yildirim ZN, Oner A, et al. Pediatric LGI1 and CASPR2 autoimmunity associated with COVID 19: Morvan syndrome [published online ahead of print, 2021 May 18]. J Neurol. 2021;1-3. doi:10.1007/s00415-021-10614-6
Dear Sirs,
Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) most commonly affects the respiratory system, autoimmune neurological presentations have also been reported [1, 2]. More recently Burr et al. have reported a pediatric patient with SARS-CoV-2-associated anti-NMDAR encephalitis [1]. Although anti-NMDAR encephalitis is one of the most common types of autoimmune encephalitis (AIE) leucine-rich glioma-inactivated protein 1 (LGI1) and contactin-associated protein 2 (CASPR2)-associated autoimmunity is rare in children. LGI1 and CASPR2 are the main antigens within the voltage-gated potassium channel-complex (VGKC). LGI1 and CASPR2 autoimmunity is associated with limbic encephalitis, isolated epilepsy, Morvan syndrome and neuromyotonia [3]. Morvan syndrome is characterized by neuromyotonia, dysautonomia, insomnia and neuropsychiatric symptoms [3, 4]. Here we present the pediatric patient with SARS-CoV-2-associated Morvan syndrome initially present with Guillain–Barre syndrome.
A previously healthy 3-year-old girl has admitted to an outside hospital for a history of sleep dysregulation and irritability followed by lower extremities weakness with difficulty in walking for 2 months ago. Her first examination had revealed tachycardia, arterial hypertension, ataxia and abolished deep tendon reflexes of the lower extremities. She had family history of coronavirus disease 2019 (COVID-19) 4 weeks before her symptoms developed...