tetano
Editor, Senior Moderator
Pediatrics. 2018 Feb 15. pii: e20170752. doi: 10.1542/peds.2017-0752. [Epub ahead of print]
Epilepsy in Children After Pandemic Influenza Vaccination.
H?berg SE[SUP]1[/SUP], Aaberg KM[SUP]2,[/SUP][SUP]3[/SUP], Sur?n P[SUP]2,[/SUP][SUP]3[/SUP], Trogstad L[SUP]2[/SUP], Ghaderi S[SUP]2[/SUP], Stoltenberg C[SUP]2,[/SUP][SUP]4[/SUP], Magnus P[SUP]2,[/SUP][SUP]5[/SUP], Bakken IJ[SUP]2[/SUP].
Author information
Abstract
OBJECTIVES:
To determine if pandemic influenza vaccination was associated with an increased risk of epilepsy in children.
METHODS:
Information from Norwegian registries from 2006 through 2014 on all children <18 years living in Norway on October 1, 2009 was used in Cox regression models to estimate hazard ratios for incident epilepsy after vaccination. A self-controlled case series analysis was used to estimate incidence rate ratios in defined risk periods after pandemic vaccination.
RESULTS:
In Norway, the main period of the influenza A subtype H1N1 pandemic was from October 2009 to December 2009. On October 1, 2009, 1 154 113 children <18 years of age were registered as residents in Norway. Of these, 572 875 (50.7%) were vaccinated against pandemic influenza. From October 2009 through 2014 there were 3628 new cases of epilepsy (incidence rate 6.09 per 10 000 person-years). The risk of epilepsy was not increased after vaccination: hazard ratio: 1.07; 95% confidence interval: 0.94-1.23. Results from the self-controlled case series analysis supported the finding of no association between vaccination and subsequent epilepsy.
CONCLUSIONS:
Pandemic influenza vaccination was not associated with increased risk of epilepsy. Concerns about pandemic vaccination causing epilepsy in children seem to be unwarranted.
Copyright ? 2018 by the American Academy of Pediatrics.
PMID: 29449342 DOI: 10.1542/peds.2017-0752
Epilepsy in Children After Pandemic Influenza Vaccination.
H?berg SE[SUP]1[/SUP], Aaberg KM[SUP]2,[/SUP][SUP]3[/SUP], Sur?n P[SUP]2,[/SUP][SUP]3[/SUP], Trogstad L[SUP]2[/SUP], Ghaderi S[SUP]2[/SUP], Stoltenberg C[SUP]2,[/SUP][SUP]4[/SUP], Magnus P[SUP]2,[/SUP][SUP]5[/SUP], Bakken IJ[SUP]2[/SUP].
Author information
Abstract
OBJECTIVES:
To determine if pandemic influenza vaccination was associated with an increased risk of epilepsy in children.
METHODS:
Information from Norwegian registries from 2006 through 2014 on all children <18 years living in Norway on October 1, 2009 was used in Cox regression models to estimate hazard ratios for incident epilepsy after vaccination. A self-controlled case series analysis was used to estimate incidence rate ratios in defined risk periods after pandemic vaccination.
RESULTS:
In Norway, the main period of the influenza A subtype H1N1 pandemic was from October 2009 to December 2009. On October 1, 2009, 1 154 113 children <18 years of age were registered as residents in Norway. Of these, 572 875 (50.7%) were vaccinated against pandemic influenza. From October 2009 through 2014 there were 3628 new cases of epilepsy (incidence rate 6.09 per 10 000 person-years). The risk of epilepsy was not increased after vaccination: hazard ratio: 1.07; 95% confidence interval: 0.94-1.23. Results from the self-controlled case series analysis supported the finding of no association between vaccination and subsequent epilepsy.
CONCLUSIONS:
Pandemic influenza vaccination was not associated with increased risk of epilepsy. Concerns about pandemic vaccination causing epilepsy in children seem to be unwarranted.
Copyright ? 2018 by the American Academy of Pediatrics.
PMID: 29449342 DOI: 10.1542/peds.2017-0752
Last edited: