tetano
Editor, Senior Moderator
Pediatrics
. 2023 Feb 1;151(2):e2022059595.
doi: 10.1542/peds.2022-059595.
Maternal and Newborn Hospital Outcomes of Perinatal SARS-CoV-2 Infection: A National Registry
Mark L Hudak[SUP] 1 [/SUP], Dustin D Flannery[SUP] 2 3 4 [/SUP], Kimberly Barnette[SUP] 1 [/SUP], Trace Getzlaff[SUP] 1 [/SUP], Shiva Gautam[SUP] 1 [/SUP], Miren B Dhudasia[SUP] 2 3 [/SUP], Sagori Mukhopadhyay[SUP] 2 3 4 [/SUP], Madeline R Pfeifer[SUP] 2 [/SUP], Sascha R Ellington[SUP] 5 [/SUP], Romeo R Galang[SUP] 5 [/SUP], Margaret C Snead[SUP] 5 [/SUP], Kate R Woodworth[SUP] 5 [/SUP], Lauren B Zapata[SUP] 5 [/SUP], Karen M Puopolo[SUP] 2 3 4 [/SUP]; AMERICAN ACADEMY OF PEDIATRICS NPC-19 REGISTRY INVESTIGATORS
Collaborators, Affiliations
Abstract
Objectives: The American Academy of Pediatrics National Registry for the Surveillance and Epidemiology of Perinatal coronavirus disease 2019 (COVID-19) (NPC-19) was developed to provide information on the effects of perinatal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Methods: National Registry for the Surveillance and Epidemiology of Perinatal COVID-19 participating centers entered maternal and newborn data for pregnant persons who tested positive for SARS-CoV-2 infection between 14 days before and 10 days after delivery. Incidence of and morbidities associated with maternal and newborn SARS-CoV-2 infection were assessed.
Results: From April 6, 2020 to March 19, 2021, 242 centers in the United States centers reported data for 7524 pregnant persons; at the time of delivery, 78.1% of these persons were asymptomatic, 18.2% were symptomatic but not hospitalized specifically for COVID-19, 3.4% were hospitalized for COVID-19 treatment, and 18 (0.2%) died in the hospital of COVID-related complications. Among 7648 newborns, 6486 (84.8%) were tested for SARS-CoV-2, and 144 (2.2%) were positive; the highest rate of newborn infection was observed when mothers first tested positive in the immediate postpartum period (17 of 125, 13.6%). No newborn deaths were attributable to SARS-CoV-2 infection. Overall, 15.6% of newborns were preterm: among tested newborns, 30.1% of polymerase chain reaction-positive and 16.2% of polymerase chain reaction-negative were born preterm (P < .001). Need for mechanical ventilation did not differ by newborn SARS-CoV-2 test result, but those with positive tests were more likely to be admitted to a NICU.
Conclusions: Early in the pandemic, SARS-CoV-2 infection was acquired by newborns at variable rates and without apparent short-term effects. During a period that preceded widespread availability of vaccines, we observed higher than expected numbers of preterm births and maternal in-hospital deaths.
. 2023 Feb 1;151(2):e2022059595.
doi: 10.1542/peds.2022-059595.
Maternal and Newborn Hospital Outcomes of Perinatal SARS-CoV-2 Infection: A National Registry
Mark L Hudak[SUP] 1 [/SUP], Dustin D Flannery[SUP] 2 3 4 [/SUP], Kimberly Barnette[SUP] 1 [/SUP], Trace Getzlaff[SUP] 1 [/SUP], Shiva Gautam[SUP] 1 [/SUP], Miren B Dhudasia[SUP] 2 3 [/SUP], Sagori Mukhopadhyay[SUP] 2 3 4 [/SUP], Madeline R Pfeifer[SUP] 2 [/SUP], Sascha R Ellington[SUP] 5 [/SUP], Romeo R Galang[SUP] 5 [/SUP], Margaret C Snead[SUP] 5 [/SUP], Kate R Woodworth[SUP] 5 [/SUP], Lauren B Zapata[SUP] 5 [/SUP], Karen M Puopolo[SUP] 2 3 4 [/SUP]; AMERICAN ACADEMY OF PEDIATRICS NPC-19 REGISTRY INVESTIGATORS
Collaborators, Affiliations
- PMID: 36995183
- DOI: 10.1542/peds.2022-059595
Abstract
Objectives: The American Academy of Pediatrics National Registry for the Surveillance and Epidemiology of Perinatal coronavirus disease 2019 (COVID-19) (NPC-19) was developed to provide information on the effects of perinatal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Methods: National Registry for the Surveillance and Epidemiology of Perinatal COVID-19 participating centers entered maternal and newborn data for pregnant persons who tested positive for SARS-CoV-2 infection between 14 days before and 10 days after delivery. Incidence of and morbidities associated with maternal and newborn SARS-CoV-2 infection were assessed.
Results: From April 6, 2020 to March 19, 2021, 242 centers in the United States centers reported data for 7524 pregnant persons; at the time of delivery, 78.1% of these persons were asymptomatic, 18.2% were symptomatic but not hospitalized specifically for COVID-19, 3.4% were hospitalized for COVID-19 treatment, and 18 (0.2%) died in the hospital of COVID-related complications. Among 7648 newborns, 6486 (84.8%) were tested for SARS-CoV-2, and 144 (2.2%) were positive; the highest rate of newborn infection was observed when mothers first tested positive in the immediate postpartum period (17 of 125, 13.6%). No newborn deaths were attributable to SARS-CoV-2 infection. Overall, 15.6% of newborns were preterm: among tested newborns, 30.1% of polymerase chain reaction-positive and 16.2% of polymerase chain reaction-negative were born preterm (P < .001). Need for mechanical ventilation did not differ by newborn SARS-CoV-2 test result, but those with positive tests were more likely to be admitted to a NICU.
Conclusions: Early in the pandemic, SARS-CoV-2 infection was acquired by newborns at variable rates and without apparent short-term effects. During a period that preceded widespread availability of vaccines, we observed higher than expected numbers of preterm births and maternal in-hospital deaths.