tetano
Editor, Senior Moderator
Pediatrics
. 2022 Apr 6;e2021053123.
doi: 10.1542/peds.2021-053123. Online ahead of print.
Two Distinct Illnesses Consistent With MIS-C in a Pediatric Patient
W Caleb Hancock[SUP] 1 2 [/SUP], Amanda M Green[SUP] 1 2 3 [/SUP], Caitlin Creel[SUP] 1 2 [/SUP], Sariha Moyen[SUP] 1 2 [/SUP], Kathleen P Collins[SUP] 1 2 [/SUP], Stephen D Pishko[SUP] 1 2 [/SUP], Terri H Finkel[SUP] 1 2 [/SUP], Bindiya Bagga[SUP] 1 2 [/SUP]
Affiliations
Abstract
Multisystem inflammatory syndrome in children (MIS-C) is a severe inflammatory response described in children after infection with severe acute respiratory syndrome coronavirus 2. We present a case of a 9-year-old African American boy with 2 distinct illnesses that were both consistent with MIS-C. He first presented in the early stages of our understanding of MIS-C with predominantly neurologic and gastrointestinal symptoms and demonstrated elevated inflammatory markers consistent with MIS-C. He was treated with intravenous immunoglobulin with complete resolution of signs and symptoms. After 7 months of good health, he returned with a second, distinct illness characterized by fever, rash, gastrointestinal symptoms, and elevated inflammatory markers that met the criteria for MIS-C. In addition, we identified new dilatation of the left anterior descending coronary artery. He improved rapidly after treatment with intravenous immunoglobulin, aspirin, and steroids. Our report highlights the need to achieve a better understanding of this entity's pathogenesis and clinical course and to improve anticipatory guidance for children with MIS-C.
. 2022 Apr 6;e2021053123.
doi: 10.1542/peds.2021-053123. Online ahead of print.
Two Distinct Illnesses Consistent With MIS-C in a Pediatric Patient
W Caleb Hancock[SUP] 1 2 [/SUP], Amanda M Green[SUP] 1 2 3 [/SUP], Caitlin Creel[SUP] 1 2 [/SUP], Sariha Moyen[SUP] 1 2 [/SUP], Kathleen P Collins[SUP] 1 2 [/SUP], Stephen D Pishko[SUP] 1 2 [/SUP], Terri H Finkel[SUP] 1 2 [/SUP], Bindiya Bagga[SUP] 1 2 [/SUP]
Affiliations
- PMID: 35383360
- DOI: 10.1542/peds.2021-053123
Abstract
Multisystem inflammatory syndrome in children (MIS-C) is a severe inflammatory response described in children after infection with severe acute respiratory syndrome coronavirus 2. We present a case of a 9-year-old African American boy with 2 distinct illnesses that were both consistent with MIS-C. He first presented in the early stages of our understanding of MIS-C with predominantly neurologic and gastrointestinal symptoms and demonstrated elevated inflammatory markers consistent with MIS-C. He was treated with intravenous immunoglobulin with complete resolution of signs and symptoms. After 7 months of good health, he returned with a second, distinct illness characterized by fever, rash, gastrointestinal symptoms, and elevated inflammatory markers that met the criteria for MIS-C. In addition, we identified new dilatation of the left anterior descending coronary artery. He improved rapidly after treatment with intravenous immunoglobulin, aspirin, and steroids. Our report highlights the need to achieve a better understanding of this entity's pathogenesis and clinical course and to improve anticipatory guidance for children with MIS-C.