tetano
Editor, Senior Moderator
PLoS One. 2018 Mar 22;13(3):e0194180. doi: 10.1371/journal.pone.0194180. eCollection 2018.
[h=1]Performance of the inFLUenza Patient-Reported Outcome (FLU-PRO) diary in patients with influenza-like illness (ILI).[/h] Powers JH 3rd[SUP]1[/SUP], Bacci ED[SUP]2[/SUP], Leidy NK[SUP]3[/SUP], Poon JL[SUP]3[/SUP], Stringer S[SUP]3[/SUP], Memoli MJ[SUP]4[/SUP], Han A[SUP]4[/SUP], Fairchok MP[SUP]5,[/SUP][SUP]6,[/SUP][SUP]7[/SUP], Coles C[SUP]6,[/SUP][SUP]7[/SUP], Owens J[SUP]6,[/SUP][SUP]7[/SUP], Chen WJ[SUP]6,[/SUP][SUP]7[/SUP], Arnold JC[SUP]8[/SUP], Danaher PJ[SUP]9[/SUP], Lalani T[SUP]7,[/SUP][SUP]10[/SUP], Burgess TH[SUP]6,[/SUP][SUP]11[/SUP], Millar EV[SUP]6,[/SUP][SUP]7[/SUP], Ridore M[SUP]12[/SUP], Hern?ndez A[SUP]13[/SUP], Rodr?guez-Zulueta P[SUP]14[/SUP], Ortega-Gallegos H[SUP]15[/SUP], Galindo-Fraga A[SUP]15[/SUP], Ruiz-Palacios GM[SUP]15[/SUP], Pett S[SUP]16,[/SUP][SUP]17,[/SUP][SUP]18,[/SUP][SUP]19,[/SUP][SUP]20[/SUP], Fischer W[SUP]17,[/SUP][SUP]21[/SUP], Gillor D[SUP]17,[/SUP][SUP]22[/SUP], Moreno Macias L[SUP]17,[/SUP][SUP]23[/SUP], DuVal A[SUP]24[/SUP], Rothman R[SUP]24[/SUP], Dugas A[SUP]24[/SUP], Guerrero ML[SUP]15[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The inFLUenza Patient Reported Outcome (FLU-PRO) measure is a daily diary assessing signs/symptoms of influenza across six body systems: Nose, Throat, Eyes, Chest/Respiratory, Gastrointestinal, Body/Systemic, developed and tested in adults with influenza.
[h=4]OBJECTIVES:[/h] This study tested the reliability, validity, and responsiveness of FLU-PRO scores in adults with influenza-like illness (ILI).
[h=4]METHODS:[/h] Data from the prospective, observational study used to develop and test the FLU-PRO in influenza virus positive patients were analyzed. Adults (≥18 years) presenting with influenza symptoms in outpatient settings in the US, UK, Mexico, and South America were enrolled, tested for influenza virus, and asked to complete the 37-item draft FLU-PRO daily for up to 14-days. Analyses were performed on data from patients testing negative. Reliability of the final, 32-item FLU-PRO was estimated using Cronbach's alpha (α; Day 1) and intraclass correlation coefficients (ICC; 2-day reproducibility). Convergent and known-groups validity were assessed using patient global assessments of influenza severity (PGA). Patient report of return to usual health was used to assess responsiveness (Day 1-7).
[h=4]RESULTS:[/h] The analytical sample included 220 ILI patients (mean age = 39.3, 64.1% female, 88.6% white). Sixty-one (28%) were hospitalized at some point in their illness. Internal consistency reliability (α) of FLU-PRO Total score was 0.90 and ranged from 0.72-0.86 for domain scores. Reproducibility (Day 1-2) was 0.64 for Total, ranging from 0.46-0.78 for domain scores. Day 1 FLU-PRO scores correlated (≥0.30) with the PGA (except Gastrointestinal) and were significantly different across PGA severity groups (Total: F = 81.7, p<0.001; subscales: F = 6.9-62.2; p<0.01). Mean score improvements Day 1-7 were significantly greater in patients reporting return to usual health compared with those who did not (p<0.05, Total and subscales, except Gastrointestinal and Eyes).
[h=4]CONCLUSIONS:[/h] Results suggest FLU-PRO scores are reliable, valid, and responsive in adults with influenza-like illness.
PMID: 29566007 DOI: 10.1371/journal.pone.0194180
[h=1]Performance of the inFLUenza Patient-Reported Outcome (FLU-PRO) diary in patients with influenza-like illness (ILI).[/h] Powers JH 3rd[SUP]1[/SUP], Bacci ED[SUP]2[/SUP], Leidy NK[SUP]3[/SUP], Poon JL[SUP]3[/SUP], Stringer S[SUP]3[/SUP], Memoli MJ[SUP]4[/SUP], Han A[SUP]4[/SUP], Fairchok MP[SUP]5,[/SUP][SUP]6,[/SUP][SUP]7[/SUP], Coles C[SUP]6,[/SUP][SUP]7[/SUP], Owens J[SUP]6,[/SUP][SUP]7[/SUP], Chen WJ[SUP]6,[/SUP][SUP]7[/SUP], Arnold JC[SUP]8[/SUP], Danaher PJ[SUP]9[/SUP], Lalani T[SUP]7,[/SUP][SUP]10[/SUP], Burgess TH[SUP]6,[/SUP][SUP]11[/SUP], Millar EV[SUP]6,[/SUP][SUP]7[/SUP], Ridore M[SUP]12[/SUP], Hern?ndez A[SUP]13[/SUP], Rodr?guez-Zulueta P[SUP]14[/SUP], Ortega-Gallegos H[SUP]15[/SUP], Galindo-Fraga A[SUP]15[/SUP], Ruiz-Palacios GM[SUP]15[/SUP], Pett S[SUP]16,[/SUP][SUP]17,[/SUP][SUP]18,[/SUP][SUP]19,[/SUP][SUP]20[/SUP], Fischer W[SUP]17,[/SUP][SUP]21[/SUP], Gillor D[SUP]17,[/SUP][SUP]22[/SUP], Moreno Macias L[SUP]17,[/SUP][SUP]23[/SUP], DuVal A[SUP]24[/SUP], Rothman R[SUP]24[/SUP], Dugas A[SUP]24[/SUP], Guerrero ML[SUP]15[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The inFLUenza Patient Reported Outcome (FLU-PRO) measure is a daily diary assessing signs/symptoms of influenza across six body systems: Nose, Throat, Eyes, Chest/Respiratory, Gastrointestinal, Body/Systemic, developed and tested in adults with influenza.
[h=4]OBJECTIVES:[/h] This study tested the reliability, validity, and responsiveness of FLU-PRO scores in adults with influenza-like illness (ILI).
[h=4]METHODS:[/h] Data from the prospective, observational study used to develop and test the FLU-PRO in influenza virus positive patients were analyzed. Adults (≥18 years) presenting with influenza symptoms in outpatient settings in the US, UK, Mexico, and South America were enrolled, tested for influenza virus, and asked to complete the 37-item draft FLU-PRO daily for up to 14-days. Analyses were performed on data from patients testing negative. Reliability of the final, 32-item FLU-PRO was estimated using Cronbach's alpha (α; Day 1) and intraclass correlation coefficients (ICC; 2-day reproducibility). Convergent and known-groups validity were assessed using patient global assessments of influenza severity (PGA). Patient report of return to usual health was used to assess responsiveness (Day 1-7).
[h=4]RESULTS:[/h] The analytical sample included 220 ILI patients (mean age = 39.3, 64.1% female, 88.6% white). Sixty-one (28%) were hospitalized at some point in their illness. Internal consistency reliability (α) of FLU-PRO Total score was 0.90 and ranged from 0.72-0.86 for domain scores. Reproducibility (Day 1-2) was 0.64 for Total, ranging from 0.46-0.78 for domain scores. Day 1 FLU-PRO scores correlated (≥0.30) with the PGA (except Gastrointestinal) and were significantly different across PGA severity groups (Total: F = 81.7, p<0.001; subscales: F = 6.9-62.2; p<0.01). Mean score improvements Day 1-7 were significantly greater in patients reporting return to usual health compared with those who did not (p<0.05, Total and subscales, except Gastrointestinal and Eyes).
[h=4]CONCLUSIONS:[/h] Results suggest FLU-PRO scores are reliable, valid, and responsive in adults with influenza-like illness.
PMID: 29566007 DOI: 10.1371/journal.pone.0194180