Pestalols A-E, new alkenyl phenol and benzaldehyde derivatives from endophytic fungus Pestalotiopsis sp. AcBC2 isolated from the Chinese mangrove plan

[tetano]

J Antibiot (Tokyo). 2014 Apr 2. doi: 10.1038/ja.2014.24. [Epub ahead of print]
Pestalols A-E, new alkenyl phenol and benzaldehyde derivatives from endophytic fungus Pestalotiopsis sp. AcBC2 isolated from the Chinese mangrove plant Aegiceras corniculatum.
Sun JF1, Lin X2, Zhou XF2, Wan J3, Zhang T3, Yang B2, Yang XW2, Tu Z3, Liu Y2.
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Abstract

Five alkenyl phenol and benzaldehyde derivatives, pestalols A-E (1-5), as well as seven known compounds (6-12), were isolated from endophytic fungus Pestalotiopsis sp. AcBC2 derived from the Chinese mangrove plant Aegiceras corniculatum. Their structures were determined by spectroscopic analyses. Compounds 2 and 3 showed cytotoxicity against a panel of 10 tumor cell lines. Compounds 1-5, 8, 9, 11, and 12 showed inhibitory activities against Influenza A virus subtype (H3N2) and Swine Flu (H1N1) viruses. Compound 2 also showed inhibitory activity against tuberculosis.The Journal of Antibiotics advance online publication, 2 April 2014; doi:10.1038/ja.2014.24.

PMID:
24690916
[PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/24690916