tetano
Editor, Senior Moderator
Sci Rep. 2016 Jun 7;6:27360. doi: 10.1038/srep27360.
[h=1]Phylogenetic analysis and pathogenicity of H3 subtype avian influenza viruses isolated from live poultry markets in China.[/h] Cui H[SUP]1[/SUP], Shi Y[SUP]1[/SUP], Ruan T[SUP]1[/SUP], Li X[SUP]1[/SUP], Teng Q[SUP]1[/SUP], Chen H[SUP]1[/SUP], Yang J[SUP]1[/SUP], Liu Q[SUP]1[/SUP], Li Z[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] H3 subtype influenza A virus is one of the main subtypes that threats both public and animal health. However, the evolution and pathogenicity of H3 avian influenza virus (AIV) circulating in domestic birds in China remain largely unclear. In this study, seven H3 AIVs (four H3N2 and three H3N8) were isolated from poultry in live poultry market (LPM) in China. Phylogenetic analyses of full genomes showed that all viruses were clustered into Eurasian lineage, except N8 genes of two H3N8 isolates fell into North American lineage. Intriguingly, the N8 gene of one H3N8 and PB2, PB1, NP and NS of two H3N2 isolates have close relationship with those of the highly pathogenic H5N8 viruses circulating in Korea and United States, suggesting that the H3-like AIV may contribute internal genes to the highly pathogenic H5N8 viruses. Phylogenetic tree of HA gene and antigenic cross-reactivity results indicated that two antigenically different H3 viruses are circulating in LPM in China. Most of the H3 viruses replicated in mice lung and nasal turbinate without prior adaptation, and the representative H3 viruses infected chickens without causing clinical signs. The reassortment of H3 subtype influenza viruses warrants continuous surveillance in LPM in China.
PMID: 27270298 [PubMed - in process] Free full text
[h=1]Phylogenetic analysis and pathogenicity of H3 subtype avian influenza viruses isolated from live poultry markets in China.[/h] Cui H[SUP]1[/SUP], Shi Y[SUP]1[/SUP], Ruan T[SUP]1[/SUP], Li X[SUP]1[/SUP], Teng Q[SUP]1[/SUP], Chen H[SUP]1[/SUP], Yang J[SUP]1[/SUP], Liu Q[SUP]1[/SUP], Li Z[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] H3 subtype influenza A virus is one of the main subtypes that threats both public and animal health. However, the evolution and pathogenicity of H3 avian influenza virus (AIV) circulating in domestic birds in China remain largely unclear. In this study, seven H3 AIVs (four H3N2 and three H3N8) were isolated from poultry in live poultry market (LPM) in China. Phylogenetic analyses of full genomes showed that all viruses were clustered into Eurasian lineage, except N8 genes of two H3N8 isolates fell into North American lineage. Intriguingly, the N8 gene of one H3N8 and PB2, PB1, NP and NS of two H3N2 isolates have close relationship with those of the highly pathogenic H5N8 viruses circulating in Korea and United States, suggesting that the H3-like AIV may contribute internal genes to the highly pathogenic H5N8 viruses. Phylogenetic tree of HA gene and antigenic cross-reactivity results indicated that two antigenically different H3 viruses are circulating in LPM in China. Most of the H3 viruses replicated in mice lung and nasal turbinate without prior adaptation, and the representative H3 viruses infected chickens without causing clinical signs. The reassortment of H3 subtype influenza viruses warrants continuous surveillance in LPM in China.
PMID: 27270298 [PubMed - in process] Free full text