tetano
Editor, Senior Moderator
Infect Genet Evol. 2014 Sep 11. pii: S1567-1348(14)00326-8. doi: 10.1016/j.meegid.2014.09.008. [Epub ahead of print]
Phylogenetic analysis of a novel H6N6 avian influenza virus isolated from a green peafowl in China and its pathogenic potential in mice.
Fan Z1, Ci Y2, Ma Y3, Liu L2, Wang D2, Ma J4, Li Y5, Chen H2.
Author information
Abstract
To explore the ecology of the H6 subtype avian influenza viruses in Hebei Province, China, a long-term surveillance was conducted in 2012 among domestic poultry and birds in a wildlife park. In this study, we report the characterization of a novel H6N6 avian influenza virus isolated from a healthy green peafowl in Qinghuangdao Wildlife Park in 2012. A phylogenetic analysis indicated that the isolated H6N6 strain has the same gene constellation as the ST3367-like strains, which are mainly distributed in southern and eastern China. A mouse experiment showed that the isolate replicated efficiently in the lungs and turbinates of infected mice without previous adaptation, resulting in locally thickened alveolar septa and interstitial pneumonia. Further studies of the H6 subtype viruses are required to clarify their evolutionary pattern in North China, which will benefit disease control and pandemic preparedness for novel viruses.
Copyright ? 2014. Published by Elsevier B.V.
KEYWORDS:
Avian influenza virus; Green peafowl; H6N6; Interstitial pneumonia; Phylogenetic analysis
PMID:
25220620
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25220620
Phylogenetic analysis of a novel H6N6 avian influenza virus isolated from a green peafowl in China and its pathogenic potential in mice.
Fan Z1, Ci Y2, Ma Y3, Liu L2, Wang D2, Ma J4, Li Y5, Chen H2.
Author information
Abstract
To explore the ecology of the H6 subtype avian influenza viruses in Hebei Province, China, a long-term surveillance was conducted in 2012 among domestic poultry and birds in a wildlife park. In this study, we report the characterization of a novel H6N6 avian influenza virus isolated from a healthy green peafowl in Qinghuangdao Wildlife Park in 2012. A phylogenetic analysis indicated that the isolated H6N6 strain has the same gene constellation as the ST3367-like strains, which are mainly distributed in southern and eastern China. A mouse experiment showed that the isolate replicated efficiently in the lungs and turbinates of infected mice without previous adaptation, resulting in locally thickened alveolar septa and interstitial pneumonia. Further studies of the H6 subtype viruses are required to clarify their evolutionary pattern in North China, which will benefit disease control and pandemic preparedness for novel viruses.
Copyright ? 2014. Published by Elsevier B.V.
KEYWORDS:
Avian influenza virus; Green peafowl; H6N6; Interstitial pneumonia; Phylogenetic analysis
PMID:
25220620
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25220620