tetano
Editor, Senior Moderator
Phys Med Rehabil Clin N Am
. 2023 Aug;34(3):623-642.
doi: 10.1016/j.pmr.2023.04.004. Epub 2023 Apr 11. Immunologic and Autoimmune-Related Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Clinical Symptoms and Mechanisms of Disease
Akshara Ramasamy[SUP] 1 [/SUP], Chumeng Wang[SUP] 1 [/SUP], W Michael Brode[SUP] 2 [/SUP], Monica Verduzco-Gutierrez[SUP] 3 [/SUP], Esther Melamed[SUP] 4 [/SUP]
Affiliations
The COVID-19 pandemic has resulted in a significant number of people developing long-term health effects of postacute sequelae SARS-CoV-2 infection (PASC). Both acute COVID-19 and PASC are now recognized as multiorgan diseases with multiple symptoms and disease causes. The development of immune dysregulation during acute COVID-19 and PASC is of high epidemiologic concern. Both conditions may also be influenced by comorbid conditions such as pulmonary dysfunction, cardiovascular disease, neuropsychiatric conditions, prior autoimmune conditions and cancer. This review discusses the clinical symptoms, pathophysiology, and risk factors that affect both acute COVID-19 and PASC.
Keywords: Autoimmunity; COVID-19; Clinical symptoms; Comorbid conditions; Disease mechanism; PASC.
. 2023 Aug;34(3):623-642.
doi: 10.1016/j.pmr.2023.04.004. Epub 2023 Apr 11. Immunologic and Autoimmune-Related Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Clinical Symptoms and Mechanisms of Disease
Akshara Ramasamy[SUP] 1 [/SUP], Chumeng Wang[SUP] 1 [/SUP], W Michael Brode[SUP] 2 [/SUP], Monica Verduzco-Gutierrez[SUP] 3 [/SUP], Esther Melamed[SUP] 4 [/SUP]
Affiliations
- PMID: 37419536
- PMCID: PMC10086105
- DOI: 10.1016/j.pmr.2023.04.004
The COVID-19 pandemic has resulted in a significant number of people developing long-term health effects of postacute sequelae SARS-CoV-2 infection (PASC). Both acute COVID-19 and PASC are now recognized as multiorgan diseases with multiple symptoms and disease causes. The development of immune dysregulation during acute COVID-19 and PASC is of high epidemiologic concern. Both conditions may also be influenced by comorbid conditions such as pulmonary dysfunction, cardiovascular disease, neuropsychiatric conditions, prior autoimmune conditions and cancer. This review discusses the clinical symptoms, pathophysiology, and risk factors that affect both acute COVID-19 and PASC.
Keywords: Autoimmunity; COVID-19; Clinical symptoms; Comorbid conditions; Disease mechanism; PASC.