tetano
Editor, Senior Moderator
Platelets
. 2020 Aug 28;1-5.
doi: 10.1080/09537104.2020.1810224. Online ahead of print.
A proof of evidence supporting abnormal immunothrombosis in severe COVID-19: naked megakaryocyte nuclei increase in the bone marrow and lungs of critically ill patients
Luca Roncati[SUP] 1 2 3 [/SUP], Giulia Ligabue[SUP] 4 [/SUP], Vincenzo Nasillo[SUP] 2 [/SUP], Beatrice Lusenti[SUP] 2 [/SUP], William Gennari[SUP] 5 [/SUP], Luca Fabbiani[SUP] 1 2 [/SUP], Claudia Malagoli[SUP] 1 2 [/SUP], Graziana Gallo[SUP] 1 [/SUP], Silvia Giovanella[SUP] 4 [/SUP], Massimo Lupi[SUP] 1 [/SUP], Tiziana Salviato[SUP] 1 [/SUP], Ambra Paolini[SUP] 2 [/SUP], Matteo Costantini[SUP] 1 [/SUP], Tommaso Trenti[SUP] 6 [/SUP], Antonio Maiorana[SUP] 1 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) is a global public health emergency with many clinical facets, and new knowledge about its pathogenetic mechanisms is deemed necessary; among these, there are certainly coagulation disorders. In the history of medicine, autopsies and tissue sampling have played a fundamental role in order to understand the pathogenesis of emerging diseases, including infectious ones; compared to the past, histopathology can be now expanded by innovative techniques and modern technologies. For the first time in worldwide literature, we provide a detailed postmortem and biopsy report on the marked increase, up to 1 order of magnitude, of naked megakaryocyte nuclei in the bone marrow and lungs from serious COVID-19 patients. Most likely related to high interleukin-6 serum levels stimulating megakaryocytopoiesis, this phenomenon concurs to explain well the pulmonary abnormal immunothrombosis in these critically ill patients, all without molecular or electron microscopy signs of megakaryocyte infection.
Keywords: Coronavirus disease 2019 (COVID-19); immunothrombosis; interleukin-6 (IL-6); megakaryocytes; naked megakaryocyte nuclei; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
. 2020 Aug 28;1-5.
doi: 10.1080/09537104.2020.1810224. Online ahead of print.
A proof of evidence supporting abnormal immunothrombosis in severe COVID-19: naked megakaryocyte nuclei increase in the bone marrow and lungs of critically ill patients
Luca Roncati[SUP] 1 2 3 [/SUP], Giulia Ligabue[SUP] 4 [/SUP], Vincenzo Nasillo[SUP] 2 [/SUP], Beatrice Lusenti[SUP] 2 [/SUP], William Gennari[SUP] 5 [/SUP], Luca Fabbiani[SUP] 1 2 [/SUP], Claudia Malagoli[SUP] 1 2 [/SUP], Graziana Gallo[SUP] 1 [/SUP], Silvia Giovanella[SUP] 4 [/SUP], Massimo Lupi[SUP] 1 [/SUP], Tiziana Salviato[SUP] 1 [/SUP], Ambra Paolini[SUP] 2 [/SUP], Matteo Costantini[SUP] 1 [/SUP], Tommaso Trenti[SUP] 6 [/SUP], Antonio Maiorana[SUP] 1 [/SUP]
Affiliations
- PMID: 32857624
- DOI: 10.1080/09537104.2020.1810224
Abstract
Coronavirus disease 2019 (COVID-19) is a global public health emergency with many clinical facets, and new knowledge about its pathogenetic mechanisms is deemed necessary; among these, there are certainly coagulation disorders. In the history of medicine, autopsies and tissue sampling have played a fundamental role in order to understand the pathogenesis of emerging diseases, including infectious ones; compared to the past, histopathology can be now expanded by innovative techniques and modern technologies. For the first time in worldwide literature, we provide a detailed postmortem and biopsy report on the marked increase, up to 1 order of magnitude, of naked megakaryocyte nuclei in the bone marrow and lungs from serious COVID-19 patients. Most likely related to high interleukin-6 serum levels stimulating megakaryocytopoiesis, this phenomenon concurs to explain well the pulmonary abnormal immunothrombosis in these critically ill patients, all without molecular or electron microscopy signs of megakaryocyte infection.
Keywords: Coronavirus disease 2019 (COVID-19); immunothrombosis; interleukin-6 (IL-6); megakaryocytes; naked megakaryocyte nuclei; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).