tetano
Editor, Senior Moderator
PLoS One
. 2024 May 22;19(5):e0303892.
doi: 10.1371/journal.pone.0303892. eCollection 2024. Acute and long-term outcomes of SARS-CoV-2 infection in school-aged children in England: Study protocol for the joint analysis of the COVID-19 schools infection survey (SIS) and the COVID-19 mapping and mitigation in schools (CoMMinS) study
Katharine J Looker[SUP] 1 2 [/SUP], Elliot McClenaghan[SUP] 3 [/SUP], Alison Judd[SUP] 4 [/SUP], Livia Pierotti[SUP] 1 2 5 [/SUP], Harriet Downing[SUP] 1 2 [/SUP], Jody Phelan[SUP] 6 [/SUP], Charlotte Warren-Gash[SUP] 7 [/SUP], Kalu Ngozi[SUP] 3 [/SUP], Fiona Dawe[SUP] 4 [/SUP], Caroline Relton[SUP] 1 5 8 9 [/SUP], Hannah Christensen[SUP] 1 [/SUP], Alastair D Hay[SUP] 1 2 [/SUP], Punam Mangtani[SUP] 3 [/SUP], Patrick Nguipdop-Djomo[SUP] 3 [/SUP], Rachel Denholm[SUP] 1 2 5 10 [/SUP]
Affiliations
Background: The symptom profiles of acute SARS-CoV-2 infection and long-COVID in children and young people (CYP), risk factors, and associated healthcare needs, are poorly defined. The Schools Infection Survey 1 (SIS-1) was a nationwide study of SARS-CoV-2 infection in primary and secondary schools in England during the 2020/21 school year. The Covid-19 Mapping and Mitigation in Schools (CoMMinS) study was conducted in schools in the Bristol area over a similar period. Both studies conducted testing to identify current and previous SARS-CoV-2 infection, and recorded symptoms and school attendance. These research data have been linked to routine electronic health record (EHR) data.
Aims: To better understand the short- and long-term consequences of SARS-CoV-2 infection, and their risk factors, in CYP.
Methods: Retrospective cohort and nested case-control analyses will be conducted for SIS-1 and CoMMinS data linked to EHR data for the association between (1) acute symptomatic SARS-CoV-2 infection and risk factors; (2) SARS-CoV-2 infection and long-term effects on health: (a) persistent symptoms; (b) any new diagnosis; (c) a new prescription in primary care; (d) health service attendance; (e) a high rate of school absence.
Results: Our study will improve understanding of long-COVID in CYP by characterising the trajectory of long-COVID in CYP in terms of things like symptoms and diagnoses of conditions. The research will inform which groups of CYP are more likely to get acute- and long-term outcomes of SARS-CoV-2 infection, and patterns of related healthcare-seeking behaviour, relevant for healthcare service planning. Digested information will be produced for affected families, doctors, schools, and the public, as appropriate.
Conclusion: Linked SIS-1 and CoMMinS data represent a unique and rich resource for understanding the impact of SARS-CoV-2 infection on children's health, benefiting from enhanced SARS-CoV-2 testing and ability to assess a wide range of outcomes.
. 2024 May 22;19(5):e0303892.
doi: 10.1371/journal.pone.0303892. eCollection 2024. Acute and long-term outcomes of SARS-CoV-2 infection in school-aged children in England: Study protocol for the joint analysis of the COVID-19 schools infection survey (SIS) and the COVID-19 mapping and mitigation in schools (CoMMinS) study
Katharine J Looker[SUP] 1 2 [/SUP], Elliot McClenaghan[SUP] 3 [/SUP], Alison Judd[SUP] 4 [/SUP], Livia Pierotti[SUP] 1 2 5 [/SUP], Harriet Downing[SUP] 1 2 [/SUP], Jody Phelan[SUP] 6 [/SUP], Charlotte Warren-Gash[SUP] 7 [/SUP], Kalu Ngozi[SUP] 3 [/SUP], Fiona Dawe[SUP] 4 [/SUP], Caroline Relton[SUP] 1 5 8 9 [/SUP], Hannah Christensen[SUP] 1 [/SUP], Alastair D Hay[SUP] 1 2 [/SUP], Punam Mangtani[SUP] 3 [/SUP], Patrick Nguipdop-Djomo[SUP] 3 [/SUP], Rachel Denholm[SUP] 1 2 5 10 [/SUP]
Affiliations
- PMID: 38776311
- PMCID: PMC11111005
- DOI: 10.1371/journal.pone.0303892
Background: The symptom profiles of acute SARS-CoV-2 infection and long-COVID in children and young people (CYP), risk factors, and associated healthcare needs, are poorly defined. The Schools Infection Survey 1 (SIS-1) was a nationwide study of SARS-CoV-2 infection in primary and secondary schools in England during the 2020/21 school year. The Covid-19 Mapping and Mitigation in Schools (CoMMinS) study was conducted in schools in the Bristol area over a similar period. Both studies conducted testing to identify current and previous SARS-CoV-2 infection, and recorded symptoms and school attendance. These research data have been linked to routine electronic health record (EHR) data.
Aims: To better understand the short- and long-term consequences of SARS-CoV-2 infection, and their risk factors, in CYP.
Methods: Retrospective cohort and nested case-control analyses will be conducted for SIS-1 and CoMMinS data linked to EHR data for the association between (1) acute symptomatic SARS-CoV-2 infection and risk factors; (2) SARS-CoV-2 infection and long-term effects on health: (a) persistent symptoms; (b) any new diagnosis; (c) a new prescription in primary care; (d) health service attendance; (e) a high rate of school absence.
Results: Our study will improve understanding of long-COVID in CYP by characterising the trajectory of long-COVID in CYP in terms of things like symptoms and diagnoses of conditions. The research will inform which groups of CYP are more likely to get acute- and long-term outcomes of SARS-CoV-2 infection, and patterns of related healthcare-seeking behaviour, relevant for healthcare service planning. Digested information will be produced for affected families, doctors, schools, and the public, as appropriate.
Conclusion: Linked SIS-1 and CoMMinS data represent a unique and rich resource for understanding the impact of SARS-CoV-2 infection on children's health, benefiting from enhanced SARS-CoV-2 testing and ability to assess a wide range of outcomes.