tetano
Editor, Senior Moderator
PLoS One
. 2022 Jul 26;17(7):e0272059.
doi: 10.1371/journal.pone.0272059. eCollection 2022.
Association between visceral fat and influenza infection in Japanese adults: A population-based cross-sectional study
Keita Kinoshita[SUP] 1 2 3 [/SUP], Naoki Ozato[SUP] 1 2 [/SUP], Tohru Yamaguchi[SUP] 2 [/SUP], Kenta Mori[SUP] 2 [/SUP], Yoshihisa Katsuragi[SUP] 1 2 [/SUP], Takuji Yasukawa[SUP] 4 [/SUP], Koichi Murashita[SUP] 5 [/SUP], Shigeyuki Nakaji[SUP] 3 [/SUP], Kazushige Ihara[SUP] 3 [/SUP]
Affiliations
Abstract
Background: Several studies have reported that obesity is associated with influenza infection; however, the role of visceral fat remains unclear. The aim of this study was to investigate the association between visceral fat and influenza infection in community-dwelling Japanese adults.
Methods: A cross-sectional study was performed using data from an annual community-based health check-up conducted from May to June in 2019. In total, 1,040 Japanese adults aged 20-89 years were enrolled in this study. Influenza infection status was determined by participants' responses to a self-administered questionnaire. The visceral fat area (VFA) was measured using a bioimpedance-type visceral fat meter. Participants were classified into four groups using the following cut-off points: VFA < 100 cm2 was set as the reference category according to the Japanese criteria, 100 ≤ VFA < 150 cm2, 150 ≤ VFA < 200 cm2, and 200 cm2 ≤ VFA. Logistic regression models were used to assess the association between VFA and influenza infection.
Results: In total, 119 participants had influenza infections in the past year. In the multivariate adjusted model, a higher VFA was significantly associated with increased influenza infection; the adjusted odds ratio for 200 cm2 ≤ VFA was 5.03 [95% confidence interval (CI): 1.07-23.6], that for 150 ≤ VFA < 200 cm2 was 1.97 (95% CI: 0.71-5.45), and that for 100 ≤ VFA < 150 cm2 was 1.62 (95% CI: 0.84-3.12), compared with that for VFA < 100 cm2 (p for trend = 0.049). These findings were confirmed in the same cohort the following year.
Conclusions: Our results suggest that visceral fat accumulation is associated with influenza infection. Large-scale prospective studies using diagnostic information for influenza infection are required to confirm this association.
. 2022 Jul 26;17(7):e0272059.
doi: 10.1371/journal.pone.0272059. eCollection 2022.
Association between visceral fat and influenza infection in Japanese adults: A population-based cross-sectional study
Keita Kinoshita[SUP] 1 2 3 [/SUP], Naoki Ozato[SUP] 1 2 [/SUP], Tohru Yamaguchi[SUP] 2 [/SUP], Kenta Mori[SUP] 2 [/SUP], Yoshihisa Katsuragi[SUP] 1 2 [/SUP], Takuji Yasukawa[SUP] 4 [/SUP], Koichi Murashita[SUP] 5 [/SUP], Shigeyuki Nakaji[SUP] 3 [/SUP], Kazushige Ihara[SUP] 3 [/SUP]
Affiliations
- PMID: 35881591
- DOI: 10.1371/journal.pone.0272059
Abstract
Background: Several studies have reported that obesity is associated with influenza infection; however, the role of visceral fat remains unclear. The aim of this study was to investigate the association between visceral fat and influenza infection in community-dwelling Japanese adults.
Methods: A cross-sectional study was performed using data from an annual community-based health check-up conducted from May to June in 2019. In total, 1,040 Japanese adults aged 20-89 years were enrolled in this study. Influenza infection status was determined by participants' responses to a self-administered questionnaire. The visceral fat area (VFA) was measured using a bioimpedance-type visceral fat meter. Participants were classified into four groups using the following cut-off points: VFA < 100 cm2 was set as the reference category according to the Japanese criteria, 100 ≤ VFA < 150 cm2, 150 ≤ VFA < 200 cm2, and 200 cm2 ≤ VFA. Logistic regression models were used to assess the association between VFA and influenza infection.
Results: In total, 119 participants had influenza infections in the past year. In the multivariate adjusted model, a higher VFA was significantly associated with increased influenza infection; the adjusted odds ratio for 200 cm2 ≤ VFA was 5.03 [95% confidence interval (CI): 1.07-23.6], that for 150 ≤ VFA < 200 cm2 was 1.97 (95% CI: 0.71-5.45), and that for 100 ≤ VFA < 150 cm2 was 1.62 (95% CI: 0.84-3.12), compared with that for VFA < 100 cm2 (p for trend = 0.049). These findings were confirmed in the same cohort the following year.
Conclusions: Our results suggest that visceral fat accumulation is associated with influenza infection. Large-scale prospective studies using diagnostic information for influenza infection are required to confirm this association.