tetano
Editor, Senior Moderator
PLoS One
. 2021 Apr 16;16(4):e0249346.
doi: 10.1371/journal.pone.0249346. eCollection 2021.
Clinical characteristics of Egyptian male patients with COVID-19 acute respiratory distress syndrome
Ahmed S Doghish[SUP] 1 2 [/SUP], Walid F Elkhatib[SUP] 3 4 [/SUP], Essam A Hassan[SUP] 5 [/SUP], Ahmed F Elkhateeb[SUP] 6 [/SUP], Eman E Mahmoud[SUP] 7 [/SUP], Mona I Ahmed[SUP] 8 [/SUP], Mahmoud A F Khalil[SUP] 9 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in severe cases associated with acute respiratory distress syndrome (ARDS).
Objective: To describe the clinical characteristics of patients with ARDS-COVID-19.
Materials and methods: This study involved 197 male Egyptian participants, among them111 COVID-19 patients presented with ARDS, 60 COVID-19 patients presented with non-ARDS, and 26 Non-COVID-19 patients. We reported the analysis results of clinical and laboratory information, including blood routine tests, blood biochemistry parameters [aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine and C-reactive protein (CRP)], thrombotic activity (D-dimer) and serum ferritin and lactate dehydrogenase (LDH).
Results: The levels of hemoglobin, AST, creatinine, monocyte count, monocyte %, RBC count, TLC, and platelet count were not significantly different among the groups. The lymphopenia and increased CRP, ALT, D-dimer, ferritin, and LDH were observed in patients with ARDS-COVID-19.
Conclusion: COVID-19 patients with ARDS presented with lymphopenia, increased thrombotic activity, increased CRP, LDH, and ferritin levels. The results revealed that CRP, D-dimer, LDH levels, and lymphopenia have a significant association with the COVID-19 severity and can be used as biomarkers to predict the disease severity.
. 2021 Apr 16;16(4):e0249346.
doi: 10.1371/journal.pone.0249346. eCollection 2021.
Clinical characteristics of Egyptian male patients with COVID-19 acute respiratory distress syndrome
Ahmed S Doghish[SUP] 1 2 [/SUP], Walid F Elkhatib[SUP] 3 4 [/SUP], Essam A Hassan[SUP] 5 [/SUP], Ahmed F Elkhateeb[SUP] 6 [/SUP], Eman E Mahmoud[SUP] 7 [/SUP], Mona I Ahmed[SUP] 8 [/SUP], Mahmoud A F Khalil[SUP] 9 [/SUP]
Affiliations
- PMID: 33861750
- DOI: 10.1371/journal.pone.0249346
Abstract
Background: Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in severe cases associated with acute respiratory distress syndrome (ARDS).
Objective: To describe the clinical characteristics of patients with ARDS-COVID-19.
Materials and methods: This study involved 197 male Egyptian participants, among them111 COVID-19 patients presented with ARDS, 60 COVID-19 patients presented with non-ARDS, and 26 Non-COVID-19 patients. We reported the analysis results of clinical and laboratory information, including blood routine tests, blood biochemistry parameters [aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine and C-reactive protein (CRP)], thrombotic activity (D-dimer) and serum ferritin and lactate dehydrogenase (LDH).
Results: The levels of hemoglobin, AST, creatinine, monocyte count, monocyte %, RBC count, TLC, and platelet count were not significantly different among the groups. The lymphopenia and increased CRP, ALT, D-dimer, ferritin, and LDH were observed in patients with ARDS-COVID-19.
Conclusion: COVID-19 patients with ARDS presented with lymphopenia, increased thrombotic activity, increased CRP, LDH, and ferritin levels. The results revealed that CRP, D-dimer, LDH levels, and lymphopenia have a significant association with the COVID-19 severity and can be used as biomarkers to predict the disease severity.