tetano
Editor, Senior Moderator
PLoS One
. 2021 Apr 5;16(4):e0248357.
doi: 10.1371/journal.pone.0248357. eCollection 2021.
COVID-IRS: A novel predictive score for risk of invasive mechanical ventilation in patients with COVID-19
Jos? Antonio Garcia-Gordillo[SUP] 1 [/SUP], Antonio Camiro-Z??iga[SUP] 1 [/SUP], Mercedes Aguilar-Soto[SUP] 1 [/SUP], Dalia Cuenca[SUP] 1 [/SUP], Arturo Cadena-Fern?ndez[SUP] 1 [/SUP], Latife Salame Khouri[SUP] 1 [/SUP], Jesica Naanous Rayek[SUP] 1 [/SUP], Moises Mercado[SUP] 2 [/SUP], ARMII Study Group
Affiliations
Abstract
Background: Coronavirus disease 2019 (COVID-19) is a systemic disease that can rapidly progress into acute respiratory failure and death. Timely identification of these patients is crucial for a proper administration of health-care resources.
Objective: To develop a predictive score that estimates the risk of invasive mechanical ventilation (IMV) among patients with COVID-19.
Study design: Retrospective cohort study of 401 COVID-19 patients diagnosed from March 12, to August 10, 2020. The score development cohort comprised 211 patients (52.62% of total sample) whereas the validation cohort included 190 patients (47.38% of total sample). We divided participants according to the need of invasive mechanical ventilation (IMV) and looked for potential predictive variables.
Results: We developed two predictive scores, one based on Interleukin-6 (IL-6) and the other one on the Neutrophil/Lymphocyte ratio (NLR), using the following variables: respiratory rate, SpO2/FiO2 ratio and lactic dehydrogenase (LDH). The area under the curve (AUC) in the development cohort was 0.877 (0.823-0.931) using the NLR based score and 0.891 (0.843-0.939) using the IL-6 based score. When compared with other similar scores developed for the prediction of adverse outcomes in COVID-19, the COVID-IRS scores proved to be superior in the prediction of IMV.
Conclusion: The COVID-IRS scores accurately predict the need for mechanical ventilation in COVID-19 patients using readily available variables taken upon admission. More studies testing the applicability of COVID-IRS in other centers and populations, as well as its performance as a triage tool for COVID-19 patients are needed.
. 2021 Apr 5;16(4):e0248357.
doi: 10.1371/journal.pone.0248357. eCollection 2021.
COVID-IRS: A novel predictive score for risk of invasive mechanical ventilation in patients with COVID-19
Jos? Antonio Garcia-Gordillo[SUP] 1 [/SUP], Antonio Camiro-Z??iga[SUP] 1 [/SUP], Mercedes Aguilar-Soto[SUP] 1 [/SUP], Dalia Cuenca[SUP] 1 [/SUP], Arturo Cadena-Fern?ndez[SUP] 1 [/SUP], Latife Salame Khouri[SUP] 1 [/SUP], Jesica Naanous Rayek[SUP] 1 [/SUP], Moises Mercado[SUP] 2 [/SUP], ARMII Study Group
Affiliations
- PMID: 33819261
- DOI: 10.1371/journal.pone.0248357
Abstract
Background: Coronavirus disease 2019 (COVID-19) is a systemic disease that can rapidly progress into acute respiratory failure and death. Timely identification of these patients is crucial for a proper administration of health-care resources.
Objective: To develop a predictive score that estimates the risk of invasive mechanical ventilation (IMV) among patients with COVID-19.
Study design: Retrospective cohort study of 401 COVID-19 patients diagnosed from March 12, to August 10, 2020. The score development cohort comprised 211 patients (52.62% of total sample) whereas the validation cohort included 190 patients (47.38% of total sample). We divided participants according to the need of invasive mechanical ventilation (IMV) and looked for potential predictive variables.
Results: We developed two predictive scores, one based on Interleukin-6 (IL-6) and the other one on the Neutrophil/Lymphocyte ratio (NLR), using the following variables: respiratory rate, SpO2/FiO2 ratio and lactic dehydrogenase (LDH). The area under the curve (AUC) in the development cohort was 0.877 (0.823-0.931) using the NLR based score and 0.891 (0.843-0.939) using the IL-6 based score. When compared with other similar scores developed for the prediction of adverse outcomes in COVID-19, the COVID-IRS scores proved to be superior in the prediction of IMV.
Conclusion: The COVID-IRS scores accurately predict the need for mechanical ventilation in COVID-19 patients using readily available variables taken upon admission. More studies testing the applicability of COVID-IRS in other centers and populations, as well as its performance as a triage tool for COVID-19 patients are needed.