Giuseppe
Emeritus
[Source: PLoS ONE, full text: (LINK).]
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Early Adaptive Humoral Immune Responses and Virus Clearance in Humans Recently Infected with Pandemic 2009 H1N1 Influenza Virus
by Chao Qiu, Di Tian, Yanmin Wan, Wanju Zhang, Chenli Qiu, Zhaoqin Zhu, Ruiqi Ye, Zhigang Song, Mingzhe Zhou, Songhua Yuan, Bisheng Shi, Min Wu, Yi Liu, Shimin Gu, Jun Wei, Zhitong Zhou, Xiaoyan Zhang, Zhiyong Zhang, Yunwen Hu, Zhenghong Yuan, Jianqing Xu
Few studies on the humoral immune responses in human during natural influenza infection have been reported. Here, we used serum samples from pandemic 2009 H1N1 influenza infected patients to characterize the humoral immune responses to influenza during natural infection in humans. We observed for the first time that the pandemic 2009 H1N1 influenza induced influenza A-specific IgM within days after symptoms onset, whereas the unit of IgG did not changed. The magnitude of influenza A-specific IgM antibodies might have a value in predicting the rate of virus clearance to some degree. However, the newly developed IgM was not associated with hemagglutination inhibition (HI) activities in the same samples but correlated with HI activities of subsequently collected sera which were mediated by IgG antibodies, indicating that IgM was critical for influenza infection and influences subsequent IgG antibody responses. These findings provide new important insights on the human immunity to natural influenza infection.
-by Chao Qiu, Di Tian, Yanmin Wan, Wanju Zhang, Chenli Qiu, Zhaoqin Zhu, Ruiqi Ye, Zhigang Song, Mingzhe Zhou, Songhua Yuan, Bisheng Shi, Min Wu, Yi Liu, Shimin Gu, Jun Wei, Zhitong Zhou, Xiaoyan Zhang, Zhiyong Zhang, Yunwen Hu, Zhenghong Yuan, Jianqing Xu
Few studies on the humoral immune responses in human during natural influenza infection have been reported. Here, we used serum samples from pandemic 2009 H1N1 influenza infected patients to characterize the humoral immune responses to influenza during natural infection in humans. We observed for the first time that the pandemic 2009 H1N1 influenza induced influenza A-specific IgM within days after symptoms onset, whereas the unit of IgG did not changed. The magnitude of influenza A-specific IgM antibodies might have a value in predicting the rate of virus clearance to some degree. However, the newly developed IgM was not associated with hemagglutination inhibition (HI) activities in the same samples but correlated with HI activities of subsequently collected sera which were mediated by IgG antibodies, indicating that IgM was critical for influenza infection and influences subsequent IgG antibody responses. These findings provide new important insights on the human immunity to natural influenza infection.
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