tetano
Editor, Senior Moderator
PLoS One
. 2023 Sep 27;18(9):e0292017.
doi: 10.1371/journal.pone.0292017. eCollection 2023. Higher in-hospital mortality in SARS-CoV-2 omicron variant infection compared to influenza infection-Insights from the CORONA Germany study
Jannis Dickow[SUP] 1 [/SUP], Melanie A Gunawardene[SUP] 1 [/SUP], Stephan Willems[SUP] 1 2 [/SUP], Johannes Feldhege[SUP] 3 [/SUP], Peter Wohlmuth[SUP] 2 3 [/SUP], Martin Bachmann[SUP] 4 [/SUP], Martin W Bergmann[SUP] 5 6 [/SUP], Wolfgang Gesierich[SUP] 7 [/SUP], Lorenz Nowak[SUP] 8 [/SUP], Ulrich-Frank Pape[SUP] 9 [/SUP], Ruediger Schreiber[SUP] 10 [/SUP], Sebastian Wirtz[SUP] 11 [/SUP], Raphael Twerenbold[SUP] 12 [/SUP], Sara Sheikhzadeh[SUP] 2 3 13 [/SUP], Nele Gessler[SUP] 1 2 3 [/SUP]
Affiliations
Background: With the emergence of new subvariants, the disease severity of Severe Acute Respiratory Syndrome Coronavirus-2 has attenuated. This study aimed to compare the disease severity in patients hospitalized with omicron variant infection to those with influenza infection.
Methods: We compared data from the multicenter observational, prospective, epidemiological "CORONA Germany" (Clinical Outcome and Risk in hospitalized COVID-19 patients) study on patients infected with Severe Acute Respiratory Syndrome Coronavirus-2 to retrospective data on influenza infection cases from November 2016 to August 2022. Severe Acute Respiratory Syndrome Coronavirus-2 cases were classified as wild-type/delta variant before January 2022, or omicron variant from January 2022 onward. The primary outcome was in-hospital mortality, adjusted for age, gender, and comorbidities.
Results: The study included 35,806 patients from 53 hospitals in Germany, including 4,916 patients (13.7%) with influenza infection, 16,654 patients (46.5%) with wild-type/delta variant infection, and 14,236 patients (39.8%) with omicron variant infection. In-hospital mortality was highest in patients with wild-type/delta variant infection (16.8%), followed by patients with omicron variant infection (8.4%) and patients with influenza infection (4.7%). In the adjusted analysis, higher age was the strongest predictor for in-hospital mortality (age 80 years vs. age 50 years: OR 4.25, 95% CI 3.10-5.83). Both, patients with wild-type/delta variant infection (OR 3.54, 95% CI 3.02-4.15) and patients with omicron variant infection (OR 1.56, 95% CI 1.32-1.84) had a higher risk for in-hospital mortality than patients with influenza infection.
Conclusion: After adjusting for age, gender and comorbidities, patients with wild-type/delta variant infection had the highest risk for in-hospital mortality compared to patients with influenza infection. Even for patients with omicron variant infection, the adjusted risk for in-hospital mortality was higher than for patients with influenza infection. The adjusted risk for in-hospital mortality showed a strong age dependency across all virus types and variants.
Trial registration number: NCT04659187.
. 2023 Sep 27;18(9):e0292017.
doi: 10.1371/journal.pone.0292017. eCollection 2023. Higher in-hospital mortality in SARS-CoV-2 omicron variant infection compared to influenza infection-Insights from the CORONA Germany study
Jannis Dickow[SUP] 1 [/SUP], Melanie A Gunawardene[SUP] 1 [/SUP], Stephan Willems[SUP] 1 2 [/SUP], Johannes Feldhege[SUP] 3 [/SUP], Peter Wohlmuth[SUP] 2 3 [/SUP], Martin Bachmann[SUP] 4 [/SUP], Martin W Bergmann[SUP] 5 6 [/SUP], Wolfgang Gesierich[SUP] 7 [/SUP], Lorenz Nowak[SUP] 8 [/SUP], Ulrich-Frank Pape[SUP] 9 [/SUP], Ruediger Schreiber[SUP] 10 [/SUP], Sebastian Wirtz[SUP] 11 [/SUP], Raphael Twerenbold[SUP] 12 [/SUP], Sara Sheikhzadeh[SUP] 2 3 13 [/SUP], Nele Gessler[SUP] 1 2 3 [/SUP]
Affiliations
- PMID: 37756299
- DOI: 10.1371/journal.pone.0292017
Background: With the emergence of new subvariants, the disease severity of Severe Acute Respiratory Syndrome Coronavirus-2 has attenuated. This study aimed to compare the disease severity in patients hospitalized with omicron variant infection to those with influenza infection.
Methods: We compared data from the multicenter observational, prospective, epidemiological "CORONA Germany" (Clinical Outcome and Risk in hospitalized COVID-19 patients) study on patients infected with Severe Acute Respiratory Syndrome Coronavirus-2 to retrospective data on influenza infection cases from November 2016 to August 2022. Severe Acute Respiratory Syndrome Coronavirus-2 cases were classified as wild-type/delta variant before January 2022, or omicron variant from January 2022 onward. The primary outcome was in-hospital mortality, adjusted for age, gender, and comorbidities.
Results: The study included 35,806 patients from 53 hospitals in Germany, including 4,916 patients (13.7%) with influenza infection, 16,654 patients (46.5%) with wild-type/delta variant infection, and 14,236 patients (39.8%) with omicron variant infection. In-hospital mortality was highest in patients with wild-type/delta variant infection (16.8%), followed by patients with omicron variant infection (8.4%) and patients with influenza infection (4.7%). In the adjusted analysis, higher age was the strongest predictor for in-hospital mortality (age 80 years vs. age 50 years: OR 4.25, 95% CI 3.10-5.83). Both, patients with wild-type/delta variant infection (OR 3.54, 95% CI 3.02-4.15) and patients with omicron variant infection (OR 1.56, 95% CI 1.32-1.84) had a higher risk for in-hospital mortality than patients with influenza infection.
Conclusion: After adjusting for age, gender and comorbidities, patients with wild-type/delta variant infection had the highest risk for in-hospital mortality compared to patients with influenza infection. Even for patients with omicron variant infection, the adjusted risk for in-hospital mortality was higher than for patients with influenza infection. The adjusted risk for in-hospital mortality showed a strong age dependency across all virus types and variants.
Trial registration number: NCT04659187.