tetano
Editor, Senior Moderator
PLoS One
. 2021 Apr 15;16(4):e0249799.
doi: 10.1371/journal.pone.0249799. eCollection 2021.
I-FABP is decreased in COVID-19 patients, independently of the prognosis
Kevin Guedj[SUP] 1 [/SUP], Mathieu Uzzan[SUP] 2 [/SUP], Damien Soudan[SUP] 2 [/SUP], Catherine Trichet[SUP] 3 [/SUP], Antonino Nicoletti[SUP] 1 [/SUP], Emmanuel Weiss[SUP] 4 [/SUP], Hana Manceau[SUP] 5 6 [/SUP], Alexandre Nuzzo[SUP] 2 [/SUP], Olivier Corcos[SUP] 2 [/SUP], Xavier Treton[SUP] 2 5 [/SUP], Katell Peoc'h[SUP] 5 6 [/SUP]
Affiliations
Abstract
Background: Severe acute respiratory syndrome caused by the novel coronavirus (SARS-CoV-2) is frequently associated with gastrointestinal manifestations. Herein we evaluated the interest in measuring the intestinal fatty acid-binding protein (I-FABP), a biomarker of intestinal injury, in COVID-19 patients.
Methods: Serum I-FABP was analyzed in 28 consecutive patients hospitalized for a PCR-confirmed COVID-19, in 24 hospitalized patients with non-COVID-19 pulmonary diseases, and 79 patients admitted to the emergency room for abdominal pain.
Results: I-FABP serum concentrations were significantly lower in patients with COVID-19, as compared to patients with non-COVID-19 pulmonary diseases [70.3 pg/mL (47-167.9) vs. 161.1 pg/mL (88.98-305.2), respectively, p = 0.008]. I-FABP concentrations in these two populations were significantly lower than in patients with abdominal pain without COVID-19 [344.8 pg/mL (268.9-579.6)]. I-FABP was neither associated with severity nor the duration of symptoms. I-FABP was correlated with polymorphonuclear cell counts.
Conclusions: In this pilot study, we observed a low I-FABP concentration in COVID-19 patients either with or without gastrointestinal symptoms, of which the pathophysiological mechanisms and clinical impact remain to be established. Further explorations on a larger cohort of patients will be needed to unravel the molecular mechanism of such observation, including the effects of malabsorption and/or abnormal lipid metabolism.
. 2021 Apr 15;16(4):e0249799.
doi: 10.1371/journal.pone.0249799. eCollection 2021.
I-FABP is decreased in COVID-19 patients, independently of the prognosis
Kevin Guedj[SUP] 1 [/SUP], Mathieu Uzzan[SUP] 2 [/SUP], Damien Soudan[SUP] 2 [/SUP], Catherine Trichet[SUP] 3 [/SUP], Antonino Nicoletti[SUP] 1 [/SUP], Emmanuel Weiss[SUP] 4 [/SUP], Hana Manceau[SUP] 5 6 [/SUP], Alexandre Nuzzo[SUP] 2 [/SUP], Olivier Corcos[SUP] 2 [/SUP], Xavier Treton[SUP] 2 5 [/SUP], Katell Peoc'h[SUP] 5 6 [/SUP]
Affiliations
- PMID: 33857216
- DOI: 10.1371/journal.pone.0249799
Abstract
Background: Severe acute respiratory syndrome caused by the novel coronavirus (SARS-CoV-2) is frequently associated with gastrointestinal manifestations. Herein we evaluated the interest in measuring the intestinal fatty acid-binding protein (I-FABP), a biomarker of intestinal injury, in COVID-19 patients.
Methods: Serum I-FABP was analyzed in 28 consecutive patients hospitalized for a PCR-confirmed COVID-19, in 24 hospitalized patients with non-COVID-19 pulmonary diseases, and 79 patients admitted to the emergency room for abdominal pain.
Results: I-FABP serum concentrations were significantly lower in patients with COVID-19, as compared to patients with non-COVID-19 pulmonary diseases [70.3 pg/mL (47-167.9) vs. 161.1 pg/mL (88.98-305.2), respectively, p = 0.008]. I-FABP concentrations in these two populations were significantly lower than in patients with abdominal pain without COVID-19 [344.8 pg/mL (268.9-579.6)]. I-FABP was neither associated with severity nor the duration of symptoms. I-FABP was correlated with polymorphonuclear cell counts.
Conclusions: In this pilot study, we observed a low I-FABP concentration in COVID-19 patients either with or without gastrointestinal symptoms, of which the pathophysiological mechanisms and clinical impact remain to be established. Further explorations on a larger cohort of patients will be needed to unravel the molecular mechanism of such observation, including the effects of malabsorption and/or abnormal lipid metabolism.