tetano
Editor, Senior Moderator
PLoS One
. 2021 Feb 26;16(2):e0247800.
doi: 10.1371/journal.pone.0247800. eCollection 2021.
Myocardial injury in hospitalized patients with COVID-19 infection-Risk factors and outcomes
Orly Efros[SUP] 1 2 [/SUP], Noam Barda[SUP] 3 [/SUP], Eshcar Meisel[SUP] 1 2 [/SUP], Avshalom Leibowitz[SUP] 1 2 [/SUP], Alexander Fardman[SUP] 1 2 [/SUP], Galia Rahav[SUP] 1 2 [/SUP], Robert Klempfner[SUP] 1 2 [/SUP], Ehud Grossman[SUP] 1 2 [/SUP]
Affiliations
Abstract
Myocardial injury in hospitalized patients is associated with poor prognosis. This study aimed to evaluate risk factors for myocardial injury in hospitalized patients with coronavirus disease 2019 (COVID-19) and its prognostic value. We retrieved all consecutive patients who were hospitalized in internal medicine departments in a tertiary medical center from February 9th, 2020 to August 28th with a diagnosis of COVID-19. A total of 559 adult patients were hospitalized in the Sheba Medical Center with a diagnosis of COVID-19, 320 (57.24%) of whom were tested for troponin levels within 24-hours of admission, and 91 (28.44%) had elevated levels. Predictors for elevated troponin levels were age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.01-1.06), female sex (OR, 3.03; 95% CI 1.54-6.25), low systolic blood pressure (OR, 5.91; 95% CI 2.42-14.44) and increased creatinine level (OR, 2.88; 95% CI 1.44-5.73). The risk for death (hazard ratio
4.32, 95% CI 2.08-8.99) and a composite outcome of invasive ventilation support and death (HR 1.96, 95% CI 1.15-3.37) was significantly higher among patients who had elevated troponin levels. In conclusion, in hospitalized patients with COVID-19, elevated troponin levels are associated with poor prognosis. Hence, troponin levels may be used as an additional tool for risk stratification and a decision guide in patients hospitalized with COVID-19.
. 2021 Feb 26;16(2):e0247800.
doi: 10.1371/journal.pone.0247800. eCollection 2021.
Myocardial injury in hospitalized patients with COVID-19 infection-Risk factors and outcomes
Orly Efros[SUP] 1 2 [/SUP], Noam Barda[SUP] 3 [/SUP], Eshcar Meisel[SUP] 1 2 [/SUP], Avshalom Leibowitz[SUP] 1 2 [/SUP], Alexander Fardman[SUP] 1 2 [/SUP], Galia Rahav[SUP] 1 2 [/SUP], Robert Klempfner[SUP] 1 2 [/SUP], Ehud Grossman[SUP] 1 2 [/SUP]
Affiliations
- PMID: 33635914
- DOI: 10.1371/journal.pone.0247800
Abstract
Myocardial injury in hospitalized patients is associated with poor prognosis. This study aimed to evaluate risk factors for myocardial injury in hospitalized patients with coronavirus disease 2019 (COVID-19) and its prognostic value. We retrieved all consecutive patients who were hospitalized in internal medicine departments in a tertiary medical center from February 9th, 2020 to August 28th with a diagnosis of COVID-19. A total of 559 adult patients were hospitalized in the Sheba Medical Center with a diagnosis of COVID-19, 320 (57.24%) of whom were tested for troponin levels within 24-hours of admission, and 91 (28.44%) had elevated levels. Predictors for elevated troponin levels were age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.01-1.06), female sex (OR, 3.03; 95% CI 1.54-6.25), low systolic blood pressure (OR, 5.91; 95% CI 2.42-14.44) and increased creatinine level (OR, 2.88; 95% CI 1.44-5.73). The risk for death (hazard ratio
4.32, 95% CI 2.08-8.99) and a composite outcome of invasive ventilation support and death (HR 1.96, 95% CI 1.15-3.37) was significantly higher among patients who had elevated troponin levels. In conclusion, in hospitalized patients with COVID-19, elevated troponin levels are associated with poor prognosis. Hence, troponin levels may be used as an additional tool for risk stratification and a decision guide in patients hospitalized with COVID-19.