tetano
Editor, Senior Moderator
PLoS One
. 2022 Feb 2;17(2):e0263127.
doi: 10.1371/journal.pone.0263127. eCollection 2022.
Prevalences of SARS-CoV-2 RNA and anti-SARS-CoV-2 among at-risk populations in Chiang Mai and Lamphun provinces, Thailand, during November 2020-January 2021
Siriluk Takalay[SUP] 1 [/SUP], Nicole Ngo-Giang-Huong[SUP] 1 2 3 [/SUP], Wanlee Kongnim[SUP] 1 [/SUP], Paporn Mongkolwat[SUP] 1 [/SUP], Porntip Phoseng[SUP] 1 [/SUP], Nantawan Wangsaeng[SUP] 3 [/SUP], Sayamon Hongjaisee[SUP] 4 [/SUP], Bordin Butr-Indr[SUP] 1 5 [/SUP], Khajornsak Tragoolpua[SUP] 1 5 [/SUP], Gonzague Jourdain[SUP] 1 2 3 [/SUP], Sakorn Pornprasert[SUP] 1 [/SUP], Woottichai Khamduang[SUP] 1 3 5 [/SUP]
Affiliations
Abstract
Non-healthcare workers with a high potential for exposure to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) may contribute to the virus spreading. Data among asymptomatic and high exposure risk populations is still scarce, in particular Chiang Mai and Lamphun provinces, Thailand. We conducted a cross-sectional observational study aiming to assess the prevalence of SARS-CoV-2 RNA positivity, anti-SARS-CoV-2 IgM/IgG, and potential associated factors among asymptomatic/mild symptomatic individuals with a high exposure risk in Chiang Mai and Lamphun provinces, during the second wave of outbreak in Thailand (November 2020-January 2021). Socio-demographic data was collected through an on-line questionnaire prior to collection of nasopharyngeal/throat swab samples and blood samples tested for SARS-CoV-2 RNA (DaAn Gene, China) and anti-SARS-CoV-2 IgM/IgG antibodies (commercial lateral flow immunoassays), respectively. Univariable and multivariable logistic regression analysis were used to analyze associated factors. None of 1,651 participants were found positive for SARS-CoV-2 RNA (0%, 95% confidence intervals, CI: 0-0.2). Fourteen were positive for anti-SARS-CoV-2 IgM/IgG antibodies (0.9%, 95% CI: 0.5-1.4), including 7 positives for IgM and 7 positives for IgG (0.4%, 95% CI: 0.2-0.9). Being over 50 years old was independently associated with virus exposure (OR: 5.8, 95% CI: 1.0-32.1%, p = 0.045). Despite high exposure risk, no current infection was found, and a very high proportion was still susceptible to SARS-CoV-2 infection and would clearly benefit from vaccination. Continuing active surveillance, rolling out of vaccination and monitoring response to vaccine will help better control the COVID-19 spread.
. 2022 Feb 2;17(2):e0263127.
doi: 10.1371/journal.pone.0263127. eCollection 2022.
Prevalences of SARS-CoV-2 RNA and anti-SARS-CoV-2 among at-risk populations in Chiang Mai and Lamphun provinces, Thailand, during November 2020-January 2021
Siriluk Takalay[SUP] 1 [/SUP], Nicole Ngo-Giang-Huong[SUP] 1 2 3 [/SUP], Wanlee Kongnim[SUP] 1 [/SUP], Paporn Mongkolwat[SUP] 1 [/SUP], Porntip Phoseng[SUP] 1 [/SUP], Nantawan Wangsaeng[SUP] 3 [/SUP], Sayamon Hongjaisee[SUP] 4 [/SUP], Bordin Butr-Indr[SUP] 1 5 [/SUP], Khajornsak Tragoolpua[SUP] 1 5 [/SUP], Gonzague Jourdain[SUP] 1 2 3 [/SUP], Sakorn Pornprasert[SUP] 1 [/SUP], Woottichai Khamduang[SUP] 1 3 5 [/SUP]
Affiliations
- PMID: 35108302
- DOI: 10.1371/journal.pone.0263127
Abstract
Non-healthcare workers with a high potential for exposure to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) may contribute to the virus spreading. Data among asymptomatic and high exposure risk populations is still scarce, in particular Chiang Mai and Lamphun provinces, Thailand. We conducted a cross-sectional observational study aiming to assess the prevalence of SARS-CoV-2 RNA positivity, anti-SARS-CoV-2 IgM/IgG, and potential associated factors among asymptomatic/mild symptomatic individuals with a high exposure risk in Chiang Mai and Lamphun provinces, during the second wave of outbreak in Thailand (November 2020-January 2021). Socio-demographic data was collected through an on-line questionnaire prior to collection of nasopharyngeal/throat swab samples and blood samples tested for SARS-CoV-2 RNA (DaAn Gene, China) and anti-SARS-CoV-2 IgM/IgG antibodies (commercial lateral flow immunoassays), respectively. Univariable and multivariable logistic regression analysis were used to analyze associated factors. None of 1,651 participants were found positive for SARS-CoV-2 RNA (0%, 95% confidence intervals, CI: 0-0.2). Fourteen were positive for anti-SARS-CoV-2 IgM/IgG antibodies (0.9%, 95% CI: 0.5-1.4), including 7 positives for IgM and 7 positives for IgG (0.4%, 95% CI: 0.2-0.9). Being over 50 years old was independently associated with virus exposure (OR: 5.8, 95% CI: 1.0-32.1%, p = 0.045). Despite high exposure risk, no current infection was found, and a very high proportion was still susceptible to SARS-CoV-2 infection and would clearly benefit from vaccination. Continuing active surveillance, rolling out of vaccination and monitoring response to vaccine will help better control the COVID-19 spread.