Giuseppe
Emeritus
[Source: PLoS ONE, full text: (LINK). Abstract, edited.]
------
Screen Anti-influenza Lead Compounds That Target the PA<SUB>C</SUB> Subunit of H5N1 Viral RNA Polymerase
Lin Li<SUP>1</SUP><SUP>,</SUP><SUP>3</SUP><SUP>#</SUP>, Shenghai Chang<SUP>2</SUP><SUP>,</SUP><SUP>3</SUP><SUP>#</SUP>, Junfeng Xiang<SUP>1</SUP>, Qian Li<SUP>1</SUP><SUP>,</SUP><SUP>3</SUP>, Huanhuan Liang<SUP>2</SUP>, Yalin Tang<SUP>1</SUP><SUP>*</SUP>, Yingfang Liu<SUP>2</SUP><SUP>*</SUP>
<SUP></SUP>
1 Beijing National Laboratory for Molecular Sciences (BNLMS), Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China, 2 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 3 Graduate University, Chinese Academy of Sciences, Beijing, P. R. China
Abstract
The avian influenza (H5N1) viral RNA polymerase protein PA<SUB>C</SUB> was used as a target to screen nine chlorogenic acid derivatives for their polymerase inhibitor activity. Among them, seven compounds were PA<SUB>C</SUB> ligands, and four inhibited influenza RNA polymerase activity. These results aid in the design of anti-influenza agents based on caffeoylquinic acid.
Citation: Li L, Chang S, Xiang J, Li Q, Liang H, et al. (2012) Screen Anti-influenza Lead Compounds That Target the PA<SUB>C</SUB> Subunit of H5N1 Viral RNA Polymerase. PLoS ONE 7(8): e35234. doi:10.1371/journal.pone.0035234
Editor: Jun Liu, Johns Hopkins School of Medicine, United States of America
Received: June 26, 2011; Accepted: March 13, 2012; Published: August 24, 2012
Copyright: ? 2012 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This work was supported by the National Natural Science Foundation of China (81072576) to Y. L. Tang, the National Natural Science Foundation of China (30925011) and the Ministry of Science and Technology 863 Project (2006AA02A314) to Y. F. Liu. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
* E-mail: tangyl@iccas.ac.cn (YLT); liuy@ibp.ac.cn (YFL)
# These authors contributed equally to this work.
-Lin Li<SUP>1</SUP><SUP>,</SUP><SUP>3</SUP><SUP>#</SUP>, Shenghai Chang<SUP>2</SUP><SUP>,</SUP><SUP>3</SUP><SUP>#</SUP>, Junfeng Xiang<SUP>1</SUP>, Qian Li<SUP>1</SUP><SUP>,</SUP><SUP>3</SUP>, Huanhuan Liang<SUP>2</SUP>, Yalin Tang<SUP>1</SUP><SUP>*</SUP>, Yingfang Liu<SUP>2</SUP><SUP>*</SUP>
<SUP></SUP>
1 Beijing National Laboratory for Molecular Sciences (BNLMS), Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China, 2 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 3 Graduate University, Chinese Academy of Sciences, Beijing, P. R. China
Abstract
The avian influenza (H5N1) viral RNA polymerase protein PA<SUB>C</SUB> was used as a target to screen nine chlorogenic acid derivatives for their polymerase inhibitor activity. Among them, seven compounds were PA<SUB>C</SUB> ligands, and four inhibited influenza RNA polymerase activity. These results aid in the design of anti-influenza agents based on caffeoylquinic acid.
Citation: Li L, Chang S, Xiang J, Li Q, Liang H, et al. (2012) Screen Anti-influenza Lead Compounds That Target the PA<SUB>C</SUB> Subunit of H5N1 Viral RNA Polymerase. PLoS ONE 7(8): e35234. doi:10.1371/journal.pone.0035234
Editor: Jun Liu, Johns Hopkins School of Medicine, United States of America
Received: June 26, 2011; Accepted: March 13, 2012; Published: August 24, 2012
Copyright: ? 2012 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This work was supported by the National Natural Science Foundation of China (81072576) to Y. L. Tang, the National Natural Science Foundation of China (30925011) and the Ministry of Science and Technology 863 Project (2006AA02A314) to Y. F. Liu. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
* E-mail: tangyl@iccas.ac.cn (YLT); liuy@ibp.ac.cn (YFL)
# These authors contributed equally to this work.
------