tetano
Editor, Senior Moderator
PLoS One
. 2021 Mar 30;16(3):e0249421.
doi: 10.1371/journal.pone.0249421. eCollection 2021.
Thyroid function analysis in COVID-19: A retrospective study from a single center
Jahanzeb Malik[SUP] 1 [/SUP], Asmara Malik[SUP] 2 [/SUP], Muhammad Javaid[SUP] 1 [/SUP], Tayyaba Zahid[SUP] 1 [/SUP], Uzma Ishaq[SUP] 3 [/SUP], Muhammad Shoaib[SUP] 4 [/SUP]
Affiliations
Abstract
Background and objective: Coronavirus disease 2019 (COVID-19) is an on-going epidemic with a multitude of long-ranging effects on the physiological balance of the human body. It can cause several effects on thyroid functions as well. We aimed to assess the lasting sequelae of COVID-19 on thyroid hormone and the clinical course of the disease as a result.
Methods: Out of 76 patients, 48 patients of COVID-19 positive and 28 patients of COVID-19 negative polymerase chain reaction (PCR) were assessed for thyroid functions, IL-6, and Procalcitonin between moderate, severe, and critical pneumonia on HRCT.
Results: Seventy-five percent of patients with COVID-19 had thyroid abnormalities and higher IL-6 levels (76.10 ? 82.35 vs. 6.99 ? 3.99, 95% CI 52.18-100.01, P-value <0.01). Logistic regression analysis suggested TT3 (P-value 0.01), IL-6 (P-value <0.01), and Procalcitonin (P-value 0.03) as independent risk factors for COVID-19. ROC curve demonstrated IL-6 as the most sensitive marker (P-value <0.01), and TT3, and Procalcitonin as the predictor for COVID-19 disease.
Conclusion: This pilot study from Pakistan demonstrates that changes in serum TSH and TT3 levels may be important manifestations of the courses of COVID-19 pneumonia.
. 2021 Mar 30;16(3):e0249421.
doi: 10.1371/journal.pone.0249421. eCollection 2021.
Thyroid function analysis in COVID-19: A retrospective study from a single center
Jahanzeb Malik[SUP] 1 [/SUP], Asmara Malik[SUP] 2 [/SUP], Muhammad Javaid[SUP] 1 [/SUP], Tayyaba Zahid[SUP] 1 [/SUP], Uzma Ishaq[SUP] 3 [/SUP], Muhammad Shoaib[SUP] 4 [/SUP]
Affiliations
- PMID: 33784355
- DOI: 10.1371/journal.pone.0249421
Abstract
Background and objective: Coronavirus disease 2019 (COVID-19) is an on-going epidemic with a multitude of long-ranging effects on the physiological balance of the human body. It can cause several effects on thyroid functions as well. We aimed to assess the lasting sequelae of COVID-19 on thyroid hormone and the clinical course of the disease as a result.
Methods: Out of 76 patients, 48 patients of COVID-19 positive and 28 patients of COVID-19 negative polymerase chain reaction (PCR) were assessed for thyroid functions, IL-6, and Procalcitonin between moderate, severe, and critical pneumonia on HRCT.
Results: Seventy-five percent of patients with COVID-19 had thyroid abnormalities and higher IL-6 levels (76.10 ? 82.35 vs. 6.99 ? 3.99, 95% CI 52.18-100.01, P-value <0.01). Logistic regression analysis suggested TT3 (P-value 0.01), IL-6 (P-value <0.01), and Procalcitonin (P-value 0.03) as independent risk factors for COVID-19. ROC curve demonstrated IL-6 as the most sensitive marker (P-value <0.01), and TT3, and Procalcitonin as the predictor for COVID-19 disease.
Conclusion: This pilot study from Pakistan demonstrates that changes in serum TSH and TT3 levels may be important manifestations of the courses of COVID-19 pneumonia.