tetano
Editor, Senior Moderator
PLoS One
. 2025 May 9;20(5):e0320196.
doi: 10.1371/journal.pone.0320196. eCollection 2025. Waning of anti-SARS-CoV-2 antibodies after the first wave of the COVID-19 pandemic in 2020: A 12-month-evaluation in three population-based European studies
Sophie Novelli[SUP] 1 [/SUP], Christina Reinkemeyer[SUP] 2 3 [/SUP], Dmitry Bulaev[SUP] 4 [/SUP], Marc Paul O'Sullivan[SUP] 4 [/SUP], Chantal J Snoeck[SUP] 4 [/SUP], Armin Rauschenberger[SUP] 4 5 [/SUP], Carmelite Manto[SUP] 6 [/SUP], Alexey Kolodkin[SUP] 4 [/SUP], Soumyabrata Ghosh[SUP] 5 [/SUP], Venkata Satagopam[SUP] 5 [/SUP], Jerome le Chenadec[SUP] 6 [/SUP], Karine Barthelemy[SUP] 7 [/SUP], Stephane Priet[SUP] 7 [/SUP], Xavier de Lamballerie[SUP] 7 [/SUP], Andreas Wieser[SUP] 2 3 8 9 [/SUP], Inge Kroidl[SUP] 2 8 [/SUP], Michel Vaillant[SUP] 4 [/SUP], Laurence Meyer[SUP] 1 [/SUP], Michael Hoelscher[SUP] 2 3 8 10 11 [/SUP], Noemi Castelletti[SUP] 2 8 12 [/SUP], Rejko Krüger[SUP] 4 13 14 [/SUP], Josiane Warszawski[SUP] 1 [/SUP]; ORCHESTRA Working Group
Affiliations
Objectives: We described waning in anti-SARS-CoV-2 IgG in adult general populations infected during the first wave of the COVID-19 pandemic in 2020 across three European countries.
Methods: Coordinated analyses were conducted separately in three population-based cohorts with complementary follow-up schedules: the KoCo19 (Germany), EpiCov (France), and CON-VINCE (Luxembourg) cohorts. Serological follow-up was based on the anti-SARS-CoV-2 ELISA-S IgG (Euroimmun) assay. We selected all adults aged 18-79 who had a positive serology (IgG optical density (OD) ratio ≥1.1) between February and July 2020, and at least one subsequent IgG measurement within the following 12 months, while still non-vaccinated.
Results: The proportion of seroreversion was 0% within the four first months, based on Koco19 data (n = 65 participants). In the longer term, 31.3% of participants had seroreverted at 6 months (95%CI: 24.4-39.1) (based on EpiCov data, n = 599), 31.3% (95%CI: 11.0-58.7) at 12 months (based on CON-VINCE data, n = 16). From EpiCov data, both baseline low IgG levels and seroneutralization negativity remained predictive of seroreversion in multivariable analysis.
Conclusion: From population-based cohorts, anti-S IgG levels remained stable during the first 4 months following SARS-CoV-2 infection. Most of the decay occurred afterward; nearly one-third of people seroreverted 6 and 12 months later. Low IgG levels and seroneutralization negativity were independent predictors of seroreversion.
. 2025 May 9;20(5):e0320196.
doi: 10.1371/journal.pone.0320196. eCollection 2025. Waning of anti-SARS-CoV-2 antibodies after the first wave of the COVID-19 pandemic in 2020: A 12-month-evaluation in three population-based European studies
Sophie Novelli[SUP] 1 [/SUP], Christina Reinkemeyer[SUP] 2 3 [/SUP], Dmitry Bulaev[SUP] 4 [/SUP], Marc Paul O'Sullivan[SUP] 4 [/SUP], Chantal J Snoeck[SUP] 4 [/SUP], Armin Rauschenberger[SUP] 4 5 [/SUP], Carmelite Manto[SUP] 6 [/SUP], Alexey Kolodkin[SUP] 4 [/SUP], Soumyabrata Ghosh[SUP] 5 [/SUP], Venkata Satagopam[SUP] 5 [/SUP], Jerome le Chenadec[SUP] 6 [/SUP], Karine Barthelemy[SUP] 7 [/SUP], Stephane Priet[SUP] 7 [/SUP], Xavier de Lamballerie[SUP] 7 [/SUP], Andreas Wieser[SUP] 2 3 8 9 [/SUP], Inge Kroidl[SUP] 2 8 [/SUP], Michel Vaillant[SUP] 4 [/SUP], Laurence Meyer[SUP] 1 [/SUP], Michael Hoelscher[SUP] 2 3 8 10 11 [/SUP], Noemi Castelletti[SUP] 2 8 12 [/SUP], Rejko Krüger[SUP] 4 13 14 [/SUP], Josiane Warszawski[SUP] 1 [/SUP]; ORCHESTRA Working Group
Affiliations
- PMID: 40344145
- PMCID: PMC12063904
- DOI: 10.1371/journal.pone.0320196
Objectives: We described waning in anti-SARS-CoV-2 IgG in adult general populations infected during the first wave of the COVID-19 pandemic in 2020 across three European countries.
Methods: Coordinated analyses were conducted separately in three population-based cohorts with complementary follow-up schedules: the KoCo19 (Germany), EpiCov (France), and CON-VINCE (Luxembourg) cohorts. Serological follow-up was based on the anti-SARS-CoV-2 ELISA-S IgG (Euroimmun) assay. We selected all adults aged 18-79 who had a positive serology (IgG optical density (OD) ratio ≥1.1) between February and July 2020, and at least one subsequent IgG measurement within the following 12 months, while still non-vaccinated.
Results: The proportion of seroreversion was 0% within the four first months, based on Koco19 data (n = 65 participants). In the longer term, 31.3% of participants had seroreverted at 6 months (95%CI: 24.4-39.1) (based on EpiCov data, n = 599), 31.3% (95%CI: 11.0-58.7) at 12 months (based on CON-VINCE data, n = 16). From EpiCov data, both baseline low IgG levels and seroneutralization negativity remained predictive of seroreversion in multivariable analysis.
Conclusion: From population-based cohorts, anti-S IgG levels remained stable during the first 4 months following SARS-CoV-2 infection. Most of the decay occurred afterward; nearly one-third of people seroreverted 6 and 12 months later. Low IgG levels and seroneutralization negativity were independent predictors of seroreversion.